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. 2023 Mar 13;13:1130820. doi: 10.3389/fcimb.2023.1130820

Figure 3.

Figure 3

The combination of tacrolimus and Lactobacillus plantarum 550 achieved better remission in colitis. (A, B) Body weight changes and DAI scores of mice in different treatment groups. n=8 per group. (C, D) Gross view and length of colons. n=6 per group. (E) Survival rate of mice during the experiments. (F) Representative hematoxylin and eosin-stained images (100× and 400×) of colon sections. Scale bars, 200 μm (above) and 50 μm (below). (G) Histological scores of proximal and distal colons. n=6 per group. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. The significance reported in (B), (D), (E), and (G) is for comparison all to the DSS group. DAI, disease activity index; Con, control; DSS, dextran sulfate sodium; 1Tacro, 1 mg/kg tacrolimus; 10Tacro, 10 mg/kg tacrolimus; Lacto, Lactobacillus plantarum 550.