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. 2023 Mar 13;13:1130820. doi: 10.3389/fcimb.2023.1130820

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Copyright © 2023 Lv, Zhang, He, Liu, Shao, Lv, Pu, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactobacillus plantarum 550 supplementation modulated intestinal mucosa inflammation at the transcriptional level. (A–C) Gene set enrichment analysis. NES values greater than 2 were demonstrated. The results represent pathways modulated in the (A) DSS group versus Con group, (B) DSS + Tacro group versus DSS group and (C) DSS + Tacro + Lacto group versus DSS + Tacro group. (D) Results of gene set variation analysis for selected biological processes in all groups. (E) The profile of infiltrating immune cells in the Con, DSS, DSS + Tacro and DSS + Tacro + Lacto groups. Data are presented as the mean ± SEM. *P < 0.05. NES, normalized enrichment score; Con, control; DSS, dextran sulfate sodium; Tacro, 10 mg/kg tacrolimus; Lacto, Lactobacillus plantarum 550. n=3 per group.