Table 1.

Prophylactic HPV vaccine approved for use in China.

Vaccine	bv-HPV vaccine (AS04-HPV-16/18)	qv-HPV vaccine	9v-HPV vaccine	bv-HPV vaccine (E.c)	bv-HPV vaccine (P.p)
Name	Cervarix	Gardasil	Gardasil-9	Cecolin	Walrinvax
Manufacturer	GSK, UK	MSD, USA	MSD, USA	Xiamen Innovax, China	Walvax, China
Expression system	Baculovirus	Saccharomyces cerevisiae	Saccharomyces cerevisiae	Escherichia coli	Pichia pastoris
Approved time (Global/China)	2007/2016	2006/2017	2014/2018	-/2019	-/2022
HPV types prevented	HPV16/18	HPV 6/11/16/18	HPV 6/11/16/18/ 31/33/45/52/58	HPV 16/18	HPV 16/18
Age for vaccination (China)	9~45y	9~45 y	9~45 y	9~45 y	9~30 y
Vaccination schedule	0 M,1 M, 6 M *	0 M,2 M, 6 M	0 M,2 M, 6 M	0 M,1 M, 6 M *	0 M,1 M, 6 M *
Site of inoculation	Intramuscular injection, upper arm deltoid preferred
HPV-related disease control (approved by China)	HPV16/18 related CIN1, CIN2/3, AIS and cervical cancer	HPV16/18 related CIN1, CIN2/3, AIS and cervical cancer	HPV16/18/31/33/45/52/58 related CIN1, CIN2/3, AIS and cervical cancer	HPV16/18 persistent infection, HPV16/18 related CIN1, CIN2/3, AIS, and cervical cancer	HPV16/18 related CIN1, CIN2/3, AIS and cervical cancer

* 9–14 y: two doses, 0 M, 6 M;

CIN, cervical intraepithelial neoplasia; AIS, adenocarcinoma in situ.