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. 2023 Mar 13;10:1021908. doi: 10.3389/fmed.2023.1021908

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Copyright © 2023 Gilbert, Mathes, Mahajan, Rohan, Travers and Thyagarajan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A visual representation of sirtuins localization in the cell and effects when dermal fibroblast undergoes UV-mediated damage. SIRT1 works through downregulating MMPs and by deacetylating FOXO3a and p53. SIRT7 activates p53 and the mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5) will activate SOD2.