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. 2023 Mar 13;13:1132141. doi: 10.3389/fonc.2023.1132141

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Copyright © 2023 Lin, Yang, Yang, Zhang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A variety of signal pathways regulate EMT-related transcription factors and downstream related pathways. EMT and crosstalk with TME, DNA damage repair and so on cause CRC resistance.