Table 4.

NLRP3 inhibitors.

NLRP3 inhibitors	Inhibition mechanism	Refs.
MCC950	Binds Walker B motif; NACHT ATPase inhibitor	(169)
CY-09	Binds Walker A motif; NACHT ATPase inhibitor	(170)
Tranilast	Directly binding to the NACHT domain of NLRP3	(171, 172)
Compound C	ATP-competitive AMPK inhibitor	(173)