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. 2023 Mar 13;11:1151790. doi: 10.3389/fcell.2023.1151790

FIGURE 2.

FIGURE 2

TFF2 expression in normal squamous-BE-EAC and normal gastric gland-GIM-GA progression sequence. (A) Immunohistochemistry of TFF2 staining in human tissue microarray esophageal cases, from left to right: normal squamous, BE-NFD, BE-LGD, BE-HGD, and EAC. (B) Immunohistochemistry of TFF2 staining in human tissue microarray gastric cases, from left to right: normal gastric corpus (left inset from base of the glands, right inset from the surface of the glands), GIM, and GA. All scale bars, 500 μm. (C) Analysis of the human esophageal tissue microarray with normal squamous, BE-NFD, BE-LGD, BE-HGD, and EAC tissue cores stained by immunohistochemistry for TFF2. Top: the TFF2 average IHC intensity score of each esophageal phenotype is plotted. For staining intensity, score 0 (undetectable) to 3 (most intense). Bottom: the TFF2 fraction of esophageal tissue cores with each score is plotted. Each phenotype’s total tissue core number is provided at the bottom of each column. (D) Analysis of the human gastric tissue microarray with normal, GIM, and GA tissue cores stained by immunohistochemistry for TFF2. Top: the TFF2 average IHC intensity score of each gastric phenotype is plotted. For staining intensity, score 0 (undetectable) to 3 (most intense). Bottom: the TFF2 fraction of gastric tissue cores with each score is plotted. Each phenotype’s total tissue core number is provided at the bottom of each column.