Fig. 2.

The mechanical, electrophysiological and hemodynamic results of the base model. Abbreviations: LV: Left Ventricle, RV: Right Ventricle, $C{a}_i$: Intracellular calcium concentration, and $V_m$: Transmembrane voltage. Top left: the pressure–volume loop of the LV and the RV. Top middle: the depolarization and repolarization times, where * indicates the onset of ventricular depolarization. Top right: the inflow (negative values) and outflow (positive values) velocities of the LV and RV. In bottom left, the stretch and tension of selected radially collinear nodes on the endocardium, midwall and epicardium of the anterior wall of the LV over a heartbeat. The dashed black lines indicate the cardiac systole. In the bottom right, the intracellular calcium and transmembrane potential of two heartbeats are shown for the nodes with the largest stretch and largest potential before the application of the stimulus (Nodes II and III in the supplementary material).