Table 3.
Diagnostic performance of presepsin and other biomarkers.
| Parameter | Third-Day Presepsin (761 pg/ml) | Delta Presepsin (+90.5 pg/ml) | First-Day PCT (0.73 mg/l) | Third-Day PCT (1.085 mg/l) |
|---|---|---|---|---|
| Sensitivity (95% CI) | 77.78 (52.36–93.59) | 83.53 (58.58–96.42) | 72.22 (46.52–90.31) | 66.67 (40.99–86.66) |
| Specificity (95% CI) | 71.95 (60.94–81.32) | 84.15 (74.42–91.28) | 75.0 (64.06–84.01) | 61.26 (49.70–71.94) |
| Positive Predictive Value (95% CI) | 37.84 (28.45–48.23) | 53.57 (40.21–66.44) | 39.39 (28.78–51.12) | 27.91 (20.16–37.24) |
| Negative Predictive Value (95% CI) | 93.65 (86.01–97.25) | 95.83 (89.07–98.48) | 92.31 (84.93–96.23) | 89.09 (80.59–94.14) |
| Positive Likelihood Ratio (95% CI) | 2.77 (1.81–4.24) | 5.26 (3.06–9.02) | 2.89 (1.80–4.65) | 1.72 (1.12–2.64) |
| Negative Likelihood Ratio (95% CI) | 0.31 (0.13–0.74) | 0.20 (0.07–0.56) | 0.37 (0.17–0.79) | 0.54 (0.28–1.07) |
| Accuracy (95% CI) | 73 (63.20–81.39) | 84.0 (75.32–90.57) | 74.49 (64.69–82.76) | 62.24 (51.88–71.84) |
| AUC (95% CI) | 0.772 (0.658–0.887) | 0.853 (0.751–0.955) | 0.767 (0.651–0.881) | 0.717 (0.592–0.843) |