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. 2023 Mar 13;11:1146753. doi: 10.3389/fchem.2023.1146753

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Copyright © 2023 Zhan and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathogenic mutations on Bcs1 and potential target for fungicide design. (A, B) Pathogenic mutations of BCS1L are mapped onto the ribbon diagram of mBcs1 as red spheres. The TM region, Bcs1-specific domain, AAA-LD and AAA-SD of Bcs1 are colored in cyan, green, purple and blue, respectively. Cut side view is shown in (A) and Bcs1 protomer is shown in (B). (C–E) Ribbon diagram of mBcs1 colored by sequence conservation, with most conserved residues colored in red and the least conserved residues in blue. The cut side view and bottom view of Bcs1 ring are shown in (C) and (E) respectively, and Bcs1 protomer is shown in (D). (F) Zoom in view of an unconserved pocket in AAA-SD in the close vicinity of nucleotide binding pocket of Bcs1. The bound ADP is shown as yellow sticks. The surface of Bcs1 is also colored by sequence conservation.