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. 2023 Feb 15;299(4):103025. doi: 10.1016/j.jbc.2023.103025

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Indisulam reduces ZEB1 in gastric cancer tissues, and high expression of ZEB1 decreases the overall survival of patients with gastric cancer.A, immunoblotting of ZEB1 in normal (paratumor) and tumor tissues from six patients with gastric cancer. Pt: patient, T: Tumor, N: Normal, Mean ± SD (n = 6), Student’s t test, ∗∗p < 0.01. B, gastric cancer tissues were treated with dimethyl sulfoxide (DMSO) and indisulam, and ZEB1 in tissue lysates was immunoblotted. Mean ± SD (n = 3), Student’s t test, ∗p < 0.05. C, the relative mRNA level of ZEB1 in gastric mucosa and diffuse gastric adenocarcinoma was obtained from Oncomine (https://www.oncomine.org). D, the correlation between the ZEB1 mRNA and the overall survival of patients with gastric cancer was obtained from Kaplan–Meier plotter (https://kmplot.com/analysis/).