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. 2023 Mar 13;15:1137584. doi: 10.3389/fnagi.2023.1137584

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Copyright © 2023 Ma, Zhao, Ou, Zhang, Li and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of Hypo with risk of dementia in the longitudinal study. Subgroup analyses indicated that the significance of the primary result was not altered by adjustment factor (no adjust age, sex, vascular factor, and adjust APOEε4), source of cohorts (population), age (>60 years vs. < 60 years), female (< 55%), follow up and region of Europe and Oceania. However, the pooled results tend to be reduced dementia risk in adjustment factors (adjust age, sex, vascular factor, and no adjust APOEε4), female (>55%), region of North America. The heterogeneity was reduced in the sub-analysis of adjustment factors (vascular factor), and female (>55% vs. < 55%). RR, relative risk; CI, confidence interval; AD, Alzheimer's disease; Hypo, hypothyroidism; APOEε4, apolipoprotein E gene isoform 4.