Table 2.
Vitamin B12 increases the flow of the sulfur amino acid pathway.
| Intracellular concentrations (µmol/g Hb) (mean [SD] or median [IQ]) | P value (AxB) | ||||||
|---|---|---|---|---|---|---|---|
| Metabolites | Group | MOD | SEV | CTRL | MOD | SEV | CTRL |
| HCY | A | 0.04096 (0.007656) | 0.04312 (0.01524) | 0.054 (0.05133-0.0638) | 0.0037 (**) | <0.0001 (****) | 0.0313 (*) |
| B | 0.0561 (0.01653) | 0.05762 (0.01784) | 0.067 (0.06225-0.0985) | ||||
| CYS | A | 0.5869 (0.2176) | 0.6795 (0.2867) | 0.5635 (0.04167) | 0.0029 (**) | 0.0007 (***) | 0.1253 |
| B | 0.7326 (0.2542) | 0.9097 (0.3812) | 0.8457 (0.2764) | ||||
| GSH | A | 12.52 (2.123) | 10.6 (4.292) | 15.35 (2.735) | 0.0002 (***) | <0.0001 (****) | 0.0612 |
| B | 15.1 (2.877) | 14.94 (6.213) | 16.24 (2.878) | ||||
| SAM | A | 0.002436 (0.000673) | 0.003405 (0.00225-0.00466) | 0.0018 (0.001418-0.001815) | 0.0010 (**) | 0.4954 | 0.0938 |
| B | 0.001789 (0.0003617) | 0.002673 (0.002365-0.004239) | 0.002081 (0.001825-0.00227) | ||||
| SAH | A | 0.0002819 (0.00009389) | 0.0001972 (0.00008667) | 0.0001817 (0.00003608) | 0.0722 | 0.0015 (**) | 0.0087 (**) |
| B | 0.0002293 (0.00004081) | 0.0003267 (0.0001541) | 0.0002277 (0.00004052) | ||||
| SAM : SAH | A | 9.093 (2.571) | 16.44 (12.09) | 9.632 (3.123) | 0.1511 | 0.0021 (**) | 0.7341 |
| B | 8.041 (2.28) | 8.058 (4.557) | 9.243 (2.087) | ||||
The parametric data were compared using two-tailed paired Student’s T test and represented as ± standard deviation. The nonparametric data were compared using two-tailed Wilcoxon paired test and represented as ± interquartile range. *P < 0.05; ** P < 0.01; ***P < 0.001; ****P < 0.0001. SEV, severe COVID-19; MOD, moderate COVID-19; CTRL, non-infected controls; A, endpoint A (samples added to culture medium with excipient and incubated for 24h); B, endpoint B (samples added to culture medium with B12 and incubated for 24h).