Table 3.
Subgroup analyses of leptin concentrations in CF and controls.
| Subgroup analysis of plasma levels(n) | SMD(95% CI) | P-value | I2(%) | P h | Subgroup analysis of serum levels(n) | SMD(95% CI) | P-value | I2(%) | P h |
|---|---|---|---|---|---|---|---|---|---|
| Overall (14) | Overall (15) | ||||||||
| Age | |||||||||
| Adult (9) | -0.20(-0.86,0.46) | 0.5533 | 82.90% | <0.0001 | Adult (7) | 0.13(-0.25,0.52) | 0.494 | 60.30% | 0.019 |
| Children (2) | 0.68(0.16,1.21) | 0.011 | 30.00% | 0.232 | Children (4) | -0.17(-1.07,0.73) | 0.711 | 88.20% | <0.0001 |
| Mixture (3) | -0.93 (-1.36,-0.50) | <0.0001 | 0.0% | 0.665 | Mixture (4) | 0.56(-0.21,1.33) | 0.309 | 77.5% | 0.004 |
| Sex | |||||||||
| Female (4) | 0.10(-0.30,0.49) | 0.630 | 0.0% | <0.0001 | Female (6) | 0.47(-0.17,1.12) | <0.0001 | 79. 0% | <0.0001 |
| Male (4) | 0.67(0.26,1.08) | 0.001 | 0.0% | 0.428 | Male (6) | 0.08 (-0.49,-0.66) | <0.0001 | 71.50% | 0.004 |
| Mixture (6) | -0.91(-1.71,-0.11) , | 0.026 | 87.2% | <0.0001 | Mixture (3) | -0.24(-0.47,-0.01) | <0.0001 | 0.0% | 0.614 |
| Assay approaches | |||||||||
| ELISA (5) | -0.27(-1.35,0.80) | 0.619 | 52.10% | <0.0001 | ELISA (7) | 0.27(-0.14,0.68) | 0.896 | 74.50% | 0.001 |
| RIA (9) | -0.24(-0.68,0.19) | 0.268 | 55.90% | 0.02 | RIA (8) | 0.04 (-0.55,0.63) | 0.196 | 78.90% | <0.0001 |
| Design | |||||||||
| Cross-sectional study (3) | -0.93(-1.36,-0.50) | 0.922 | 0.0% | 0.665 | Cross-sectional study (6) | 0.19(-0.50,0.87) | 0.597 | 82.90% | <0.0001 |
| Case-control study (11) | -0.03(-0.60,0.54) | <0.0001 | 83.30% | <0.0001 | Case-control study (9) | 0.17(-0.21,0.55) | 0.389 | 70.80% | 0.001 |
Ph: Pheterogeneity; RIA, radioimmunoassay; ELISA, enzyme linked immunosorbent assay.