Table 2.
Response to Treatment.*
| Variable | RVD-Alone Group (N = 357) | Transplantation Group (N = 365) | Hazard Ratio (95% CI) | Adjusted P Value† |
|---|---|---|---|---|
| Best response | ||||
| Partial response or better | 0.55‡ | |||
| No. with response | 339 | 356 | ||
| Percentage with response (95% CI) | 95.0 (91.0–97.5) | 97.5 (94.5–99.2) | ||
| Very good partial response or better | 0.99‡ | |||
| No. with response | 284 | 302 | ||
| Percentage with response (95% CI) | 79.6 (73.3–85.0) | 82.7 (76.8–87.7) | ||
| Complete response or better | 0.99‡ | |||
| No. with response | 150 | 171 | ||
| Percentage with response (95% CI) | 42.0 (35.0–49.3) | 46.8 (39.8–54.0) | ||
| Stringent complete response — no. (%) | 99 (27.7) | 120 (32.9) | ||
| Complete response — no. (%) | 51 (14.3) | 51 (14.0) | ||
| Very good partial response — no. (%) | 134 (37.5) | 131 (35.9) | ||
| Partial response — no. (%) | 55 (15.4) | 54 (14.8) | ||
| Stable disease — no. (%) | 15 (4.2) | 7 (1.9) | ||
| Progressive disease — no. (%) | 1 (0.3) | 1 (0.3) | ||
| Not evaluable — no. (%) | 2 (0.6) | 1 (0.3) | ||
| Duration of response | ||||
| Median duration of partial response or better — mo | 38.9 | 56.4 | ||
| Disease progression events — no./total no. (%) | 194/339 (57.2) | 164/356 (46.1) | 1.45 (1.09–1.93) | 0.003 |
| Complete response or better at 5 yr — % | 52.9 | 60.6 | ||
| Disease progression events — no./total no. (%) | 61/150 (40.7) | 57/171 (33.3) | 1.35 (0.83–2.22) | 0.70 |
*
Responses were assessed according to the International Myeloma Working Group criteria by a central response review committee.
†
P values were adjusted with the use of Bonferroni’s correction to control the overall family‑wise error rate for secondary outcomes.
‡
This P value was calculated with the use of Fisher’s exact test.