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. 2023 Mar 10;14:1112985. doi: 10.3389/fimmu.2023.1112985

Figure 4.

Figure 4

In-silico predictions of molecular activity across the whole DC model comparing Sars-CoV-2 and Influenza A virus (IAV) co-infection to the single infection. (A) The differential molecule expressions are grouped into three main patterns in response to each environmental setting. The first pattern grouped molecules that are regulated similarly in all three conditions. The second pattern is related to similar regulation between Influenza and co-infection, and the third one grouped similar behavior between Sars-CoV-2 and co-infection conditions. The scale represented the activity level ranging between 0 to 100%, 100 being the highest activity level. (B) The molecular signatures in pattern 1 in single and co-infection cellular environments. (C) An example of the second pattern shows that under different activity levels of Sars-CoV-2 (green, low; yellow, medium; purple, high), ICOSLG is inactive while it is upregulated in both co-infection and single IAV. (D) CLEC9A is categorized as the third pattern, and for both Sars-CoV-2 and co-infection, it has low activity levels compared to the IAV single infection.