Figure 6.

P-NF-κB-p65 inhibitor resveratrol can protect the liver from CX3CR1 deficiency–enhanced ConA-induced damage.

Cx3cr1^+/+ and Cx3cr1^−/− mice were pre-treated with 30 mg/kg body weight of resveratrol or vehicle (DMSO) seven times by intragastric administration, followed by intravenous injection with 13 mg/kg body weight of ConA. (A, B) Serum AST and ALT were measured at 8 and 24 h after ConA injection. (C, D) Serum TNF-α, IFN-γ, IL-6, IL-1β levels at 8 h (C) and 24 h (D) after ConA injection. (E) Liver necrosis was evaluated by H&E staining (original magnification: 40× and 200×). The scale bars are 500 μm (40×) and 100 μm (200×), respectively. (F) The quantification of liver necrosis area. (A color version of this figure is available in the online journal.)