FIGURE 3.

Effects of interaction between continuous variables on the edema volume. The overall results of the moderation analyses and the interaction plots summarise presence of not additive, but statistically significant synergistic interactions between CRP‐ESR (A), neutrophils‐CRP (B), NLR‐IL‐6 (C) and neutrophils‐IL‐6 (D) as drivers for the edema formation; moreover, significant antagonistic effect of high protein oxidation on the CRP‐edema dependence was detected (E‐F), suggesting a mechanism of potential redox‐CRP negative feedback loop and redox inactivation of CRP. Abbreviations: ANC, absolute neutrophil count; AOPP, advanced oxidation protein products; CRP, C‐reactive protein; ESR, erythrocyte sedimentation rate; IL, interleukin