TABLE 2.

IVD receptors, ion channels, neurotransmitters and nerve types relevant to LBP

Receptors and ion channels		Ref
RET	Proto‐oncogene “rearranged during transfection” receptor	109 , 137 , 138
GFRa1, 2, 3	Glial cell‐derived neurotrophic factor (GDNF) receptor family	157
TRKA, B, C	Tropomyosin kinase receptor family	157
VR‐1	Vanilloid receptor‐1	158 , 159
P2X family	P2X purinoreceptor family	55 , 160
5‐HTR	5‐Hydroxy tryptamine receptor	139 , 161
TRVP‐1	Transient receptor potential vanilloid‐1	162
TRP ion‐channels	Transient receptor potential ion channel family	163
ENaC	Epithelial Na+ channel	164
DEG	Degenerin, an epithelial Na+ channel	165
ASIC family	Acid‐sensing ion channels 1a, 1b, 2a, 2b, 3, 4	131 , 132 , 133 , 134 , 135 , 136 , 165 , 166
CB‐1 and CB‐2	Cannabinoid receptors 1 and 2	167 , 168
Mechano	Mechanoreceptors	115 , 118
RGD integrins	α5β1 integrin, potential mechanoreceptor	117
Sem 3A	Semaphorin receptor 3A	116
S100 positive receptors	S100 positive mechano receptors	121 , 164
Cav3.2 and CaV2.2 ion channels	Low voltage‐activated CaV3.2 channel and a high voltage‐activated CaV2.2 channel	122
Neurotransmitters
1B4	1B4 neurotransmitter, also known as Synaptotagmin I	169 , 170
CGRP	Calcitonin gene‐related peptide	171
SP	Substance‐P	172 , 173
NGF	Nerve growth factor	118 , 174 , 175 , 176
BDNF	Brain derived neurotrophic factor (abrineurin)	159 , 174 , 177 , 178
GDNF	Glial cell‐derived neurotrophic factor	157
Nerve fibers
A (σ, β) fiber	Myelinated A nerve fibers	58 , 118 , 121
C fiber	Unmyelinated nerve fibers	179