Table 3. In Vitro Metabolic Stability of 7a^a.

mouse hepatocytes
in vitro t1/2 [min]	160
Clint [μL/106 cells/min]	9.0
Clint (pred. in vivo) [mL/min]	2.1
ClH (pred.) [mL/min]	0.05
Epred	0.03

mouse liver microsomes
in vitro t1/2 [min]	87
Clint [μL/106 cells/min]	16
Clint (pred. in vivo) [mL/min]	1.3
ClH (pred.) [mL/min]	0.03
Epred	0.01

human liver microsomes
in vitro t1/2 [min]	103
Clint [μL/106 cells/min]	13
Clint (pred. in vivo) [mL/min]	630
ClH (pred.) [mL/min]	14
Epred	0.01

^aAbbreviations: t_1/2, elimination half-life; Cl_int, intrinsic clearance; Cl_H, hepatic clearance; E_pred, predicted hepatic extraction ratio (the fraction of drug removed from blood by the liver in one passage); and pred., predicted.