Table 4. Pharmacokinetic Profiling of 7a in Mice Following Intravenous (IV) Administration^a,b.

route	dose [mg/kg]	t1/2 [h]	C0 [ng/mL]	AUC0–24h [h*ng/mL]	AUC0–∞ [h*ng/mL]	Cl [mL/min/kg]	Vss [L/kg]
IV	1	1.0	913	303	304	54.8	2.3

^aMale CD-1 mice (Charles River Laboratories, USA), IV, n = 6.

^bAbbreviations: t_1/2, elimination half-life, C₀, initial concentration at time zero; AUC, area under the concentration–time curve; Cl, clearance; and V_ss, volume of distribution at steady state.