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. 2023 Mar 3;66(6):3818–3851. doi: 10.1021/acs.jmedchem.2c01360

Figure 1.

Figure 1

Cathepsin B-inhibitory dipeptide nitriles 1a (reported by Greenspan et al.86) and 1b as lead compounds for the design of dipeptide-derived alkynes 2a and 2b, respectively, as potentially irreversible inhibitors of cathepsin B. Protease subsite-targeting moieties P1–P3 are highlighted for nitrile 1a.