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Selectivity profile of dipeptide alkynes with a glycine-derived moiety at P1. The lead compound 2b is included for comparison. The measurement was performed in three independent experiments (each as a duplicate determination) in assay buffer (pH 6.0) containing 1.5% DMSO. n.i. = no inhibition; i.e., no evidence of irreversible inhibition was discernible within the considered time and concentration ranges.
