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. 2023 Mar 3;66(6):3818–3851. doi: 10.1021/acs.jmedchem.2c01360

Table 7. Additivity of Inhibitory Activities toward Cysteine Cathepsins within Compound Quartets defined in Figure 15.

quartet   CatB CatS CatL CatK
Q1 ΔΔpKi 0.14 0.21 0.11 0.24
Q2 ΔΔlog(kinact/KI) –1.55 0.09 –0.72
Q3 ΔΔpKi –0.12 0.12 0.12 1.26
Q4 ΔΔlog(kinact/KI) 0.96 –1.16 –1.17 –∞
Q5 ΔΔlog(kinact/KI) –0.44 –0.71 –0.40
Q6 ΔΔlog(kinact/KI) 1.11 0 –∞