Table 7. Additivity of Inhibitory Activities toward Cysteine Cathepsins within Compound Quartets defined in Figure 15.
quartet | CatB | CatS | CatL | CatK | |
---|---|---|---|---|---|
Q1 | ΔΔpKi | 0.14 | 0.21 | 0.11 | 0.24 |
Q2 | ΔΔlog(kinact/KI) | –1.55 | 0.09 | –0.72 | ∞ |
Q3 | ΔΔpKi | –0.12 | 0.12 | 0.12 | 1.26 |
Q4 | ΔΔlog(kinact/KI) | 0.96 | –1.16 | –1.17 | –∞ |
Q5 | ΔΔlog(kinact/KI) | –0.44 | ∞ | –0.71 | –0.40 |
Q6 | ΔΔlog(kinact/KI) | 1.11 | ∞ | 0 | –∞ |