Table 2.
Follow-up group characteristics by symptom status at follow-up.
| Characteristic | Ongoing symptomatic (symptoms reported at baseline and follow-up)(n = 264) | Resolved symptoms (no symptoms reported at follow-up)(n = 60) | p-value |
|---|---|---|---|
| Follow-up group baseline characteristics | |||
| Demographics | |||
| Age (years) | 46 (10) | 48 (12) | 0.340 |
| Female sex (n) | 204 (77%) | 34 (57%) | 0.002 |
| BMI (kg/m2) | 26 (23, 30) | 28 (23, 31) | 0.519 |
| White | 239 (91%) | 49 (82%) | 0.066 |
| Mixed | 3 (1%) | 0 (0%) | >0.999 |
| South Asian | 8 (3%) | 7 (12%) | 0.010 |
| Black | 3 (1%) | 2 (3%) | 0.232 |
| Healthcare worker | 89 (34%) | 19 (32%) | 0.880 |
| Co-morbidities and risks | |||
| Never smoked | 173 (66%) | 40 (67%) | >0.999 |
| Current smoker | 4 (2%) | 2 (3%) | 0.308 |
| Ex-smoker | 87 (33%) | 18 (30%) | 0.760 |
| BMI>=25 kg/m2 | 159 (60%) | 38 (63%) | 0.770 |
| BMI>=30 kg/m2 | 72 (27%) | 18 (30%) | 0.750 |
| Hypertension | 25 (9%) | 6 (10%) | 0.813 |
| Diabetes | 3 (1%) | 4 (7%) | 0.024 |
| Asthma | 53 (20%) | 9 (15%) | 0.468 |
| Pre-existing heart disease | 3 (1%) | 1 (2%) | 0.561 |
| Hospitalised during acute COVID-19 | 46 (17%) | 10 (17%) | >0.999 |
| Number of common symptoms reported | 10 (9, 11) | 9 (7, 10) | <0.001 |
| MRI abnormality | |||
| Liver | |||
| cT1 or fat high | 95 (36%) | 23 (39%) | 0.766 |
| cT1 (high) | 36 (14%) | 9 (15%) | 0.836 |
| cT1 (ms) | 727 (681, 770) | 715 (680, 768) | 0.690 |
| Fat (high) | 87 (33%) | 20 (33%) | >0.999 |
| Fat (%) | 3 (2, 6) | 3 (1, 6) | 0.732 |
| Volume (high) | 23 (9%) | 6 (10%) | 0.801 |
| Volume (ml) | 1423 (1252, 1693) | 1463 (1277, 1653) | 0.650 |
| Pancreas | |||
| srT1 or fat high | 64 (26%) | 14 (24%) | 0.868 |
| srT1 high | 29 (12%) | 7 (12%) | >0.999 |
| srT1 (ms) | 720 (686, 772) | 722 (684, 767) | 0.775 |
| Fat (high) | 51 (20%) | 12 (20%) | >0.999 |
| Fat (%) | 3 (2, 6) | 3 (3, 5) | 0.287 |
| Kidney | |||
| Cortex T1 (high) | 44 (17%) | 14 (24%) | 0.193 |
| Cortex T1 left 1.5T (ms) | 1084 (74) | 1094 (61) | 0.323 |
| Cortex T1 right 1.5T (ms) | 1072 (70) | 1084 (68) | 0.260 |
| Cortex T1 left 3T (ms) | 1427 (74) | 1399 (54) | 0.204 |
| Cortex T1 right 3T (ms) | 1400 (85) | 1382 (70) | 0.509 |
| Volume (high) | 21 (8%) | 7 (12%) | 0.318 |
| Volume left (ms) | 146 (129, 165) | 158 (133, 179) | 0.044 |
| Volume right (ms) | 146 (128, 166) | 150 (137, 172) | 0.185 |
| Spleen | |||
| Splenomegaly | 28 (11%) | 5 (8%) | 0.813 |
| Volume (ml) | 180 (141, 242) | 194 (166, 252) | 0.146 |
| Lung | |||
| FAC (low) | 7 (3%) | 0 (0%) | 0.359 |
| FAC (%) | 44 (36, 50) | 43 (35, 50) | 0.844 |
| Heart | |||
| Myocardial Injury/T1 (high) | 24 (9%) | 11 (18%) | 0.062 |
| Average T1 1.5T (ms) | 980 (965, 993) | 972 (949, 987) | 0.047 |
| Average T1 3T (ms) | 1182 (31) | 1184 (37) | 0.903 |
| LV EF (low) | 13 (5%) | 4 (7%) | 0.531 |
| LV EF (%) | 60 (5) | 58 (5) | 0.029 |
| RV EF (low) | 10 (4%) | 4 (7%) | 0.302 |
| RV EF (%) | 59 (5) | 58 (6) | 0.108 |
| LV EDV (high) | 2 (1%) | 0 (0%) | >0.999 |
| LV EDV (ml) | 78 (71, 87) | 82 (75, 94) | 0.008 |
| RV EDV (high) | 3 (1%) | 0 (0%) | >0.999 |
| RV EDF (ml) | 75 (66, 84) | 80 (70, 93) | 0.005 |
| Global longitudinal strain (high) | 11 (4%) | 0 (0%) | 0.230 |
| Global longitudinal strain (%) | −14 (2) | −14 (2) | 0.474 |
| Number of organs impaired on MRI | |||
| 0 | 84 (32%) | 17 (28%) | 0.646 |
| ≥1 | 180 (68%) | 43 (72%) | 0.646 |
| ≥2 | 75 (28%) | 20 (33%) | 0.438 |
| ≥3 | 26 (10%) | 7 (12%) | 0.641 |
| Follow-up characteristics | |||
| Hospitalised between baseline and follow-up | 13 (5%) | 1 (2%) | 0.480 |
| Time off work (days) | 172 (42, 300) | 54 (21, 120) | <0.001 |
| MRI abnormality | |||
| Liver | |||
| cT1 or fat high | 88 (35%) | 17 (28%) | 0.447 |
| cT1 (high) | 40 (16%) | 7 (12%) | 0.547 |
| cT1 (ms) | 724 (693, 768) | 708 (676, 755) | 0.150 |
| Fat (high) | 74 (29%) | 16 (27%) | 0.754 |
| Fat (%) | 3 (2, 6) | 3 (2, 6) | 0.877 |
| Volume (high) | 24 (9%) | 5 (8%) | >0.999 |
| Volume (ml) | 1427 (1271, 1699) | 1474 (1316, 1675) | 0.429 |
| Pancreas | |||
| srT1 or fat high | 43 (22%) | 10 (21%) | >0.999 |
| cT1 high | 16 (8%) | 4 (8%) | >0.999 |
| srT1 (ms) | 720 (684, 754) | 700 (673, 740) | 0.113 |
| Fat (high) | 35 (18%) | 10 (20%) | 0.683 |
| Fat (%) | 3 (2, 5) | 3 (2, 6) | 0.989 |
| Kidney | |||
| Cortex T1 (high) | 45 (17%) | 9 (15%) | 0.848 |
| Cortex T1 left 1.5T (ms) | 1086 (58) | 1086 (67) | 0.949 |
| Cortex T1 right 1.5T (ms) | 1082 (53) | 1078 (67) | 0.702 |
| Cortex T1 left 3T (ms) | 1422 (91) | 1424 (53) | 0.931 |
| Cortex T1 right 3T (ms) | 1404 (85) | 1393 (59) | 0.605 |
| Volume (high) | 21 (8%) | 6 (10%) | 0.610 |
| Volume left (ms) | 145 (127, 165) | 158 (137, 180) | 0.011 |
| Volume right (ms) | 149 (129, 167) | 156 (143, 172) | 0.028 |
| Spleen | |||
| Splenomegaly | 24 (9%) | 5 (8%) | >0.999 |
| Volume (ml) | 176 (139, 246) | 192 (161, 245) | 0.074 |
| Lung | |||
| FAC (low) | 4 (2%) | 0 (0%) | 0.580 |
| FAC (%) | 45 (38, 52) | 45 (38, 52) | 0.752 |
| Heart | |||
| Myocardial Injury / T1 (high) | 25 (9%) | 7 (12%) | 0.632 |
| Average T1 1.5T (ms) | 982 (969, 992) | 975 (960, 987) | 0.069 |
| Average T1 3T (ms) | 1182 (38) | 1184 (48) | 0.895 |
| LV EF (low) | 6 (2%) | 2 (3%) | 0.644 |
| LV EF (%) | 60 (4) | 58 (5) | 0.013 |
| RV EF (low) | 7 (3%) | 5 (8%) | 0.051 |
| RV EF (%) | 59 (5) | 57 (5) | 0.014 |
| LV EDV (high) | 2 (1%) | 0 (0%) | >0.999 |
| LV EDF (ml) | 78 (70, 86) | 82 (75, 92) | 0.012 |
| RV EDV (high) | 4 (2%) | 0 (0%) | >0.999 |
| RV EDF (ml) | 74 (66, 86) | 81 (72, 91) | 0.015 |
| Global longitudinal strain (high) | 15 (6%) | 5 (8%) | 0.551 |
| Global longitudinal strain (%) | −15 (2) | −14 (2) | 0.017 |
| Number of organs impaired on MRI | |||
| 0 | 112 (42%) | 23 (38%) | 0.664 |
| ≥1 | 152 (58%) | 37 (62%) | 0.664 |
| ≥2 | 73 (28%) | 13 (22%) | 0.419 |
| ≥3 | 28 (11%) | 5 (8%) | 0.813 |
Compared are the baseline characteristics (top part) and the follow-up characteristics (bottom part) between groups that at follow-up were ongoing symptomatic or had resolved symptoms. Values in red are p < 0.05.