Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 25;16:17562864231163361. doi: 10.1177/17562864231163361

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 1. — The peripheral neuropathological features and mitochondrial dysfunction of dorsal root ganglia (DRG) neurons in chemotherapy-induced peripheral neuropathy (CIPN).

The pathological characterizations of peripheral nerves in CIPN are indicated by arrows, including axonal degeneration, intraepidermal nerve fiber loss, mitochondrial swelling and vacuolization in sensory nerve endings, and impairment of mitochondrial transportation. The enlarged illustration on the upper right shows the central role of peroxisome proliferator-activated receptor gamma coactivator 1α (PGC1α) in mitochondrial dysfunction of DRG neurons in CIPN.