Table 2.

National Comprehensive Cancer Network (NCCN) guideline-based cancer surveillance completed as a direct result of cascade genetic testing (N = 25 relatives with pathogenic variants)

Recommendation for cancer screening		N	%
Relatives not recommended cancer screening		7
Relatives recommended cancer screening		18
Completed ≥1 screening		13	72.2
Completed all recommended screening		6	33.3
Completed none of the recommended screening		5	27.8
Screening interventions	# Relatives recommended	# Relatives completed	%
Mammogram	10	7	70.0
Breast magnetic resonance imaging (MRI)	10	3	30.0
Prostate specific antigen screening	1	1	100.0
Colonoscopy	5	4	80.0

^*Measured NCCN-based cancer screening interventions by mutation: BRCA1 – mammogram, breast MRI; BRCA2 – mammogram, breast MRI, prostate specific antigen for males; CHEK2 – mammogram, breast MRI, colonoscopy; APC I1307K variant – colonoscopy.