Fig. 4.

TERRA G4 stabilization disrupts TRF2 binding and leading to strong modulation of its targets. A Quantitative PCR of telomeres performed after TRF2 ChIP on NCI-H929 cell line. Results are expressed as fold change respect to IgG set as 1. B Representative images showing detection of TRF2 by immuno-FISH in hit 17 and control (DMSO) in NCI-H929 cell line. Interphase cells were stained with anti-TRF2 (green) and telomeric Cy3-labeled probe (red). Nuclei were counterstained with DAPI (blue). Scale bar, 10 μm. *P <0.05