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. 2023 Mar 27;21:109. doi: 10.1186/s12951-023-01862-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CHAC1 was up-regulated in mouse neurons at 3d after MCAO and ADSC-Exo were taken up by neurons in vivo and in vitro. A The immunofluorescence showed the co-localization of NeuN with CHAC1 obviously, while no co-localization of CHAC1 with IBA1 or GFAP was identified. White arrows indicated the co-localization of NeuN with CHAC1. Scale bars = 20 μm. B Immunofluorescence imaging showed the uptake of ADSC-Exo by neurons in vivo. PKH26 labeled ADSC-Exo (Red) were intranasally administered to the mouse at 24 h after MCAO. The internalization of ADSC-Exo by NeuN + neuron (Green) was detected 6 h after the administration. The white circle indicated ADSC-Exo internalized by neuron. Scale bar = 50 μm. C PKH‐26 labeled ADSC-Exo (Red) were taken up by NeuN + N2a cells (Green). PKH‐26 labeled ADSC-Exo were incubated with N2a cells for 6 h. Scale bar = 20 μm