Table 3.
Direction of effects in MSON vs. MSNON
| Study (Optovue) | FAZ area | Superficial foveal VD | Superficial parafoveal VD | Superficial perifoveal VD | Superficial whole VD | Deep fovea VD | Deep parafoveal VD | Deep perifoveal VD | Deep whole VD | Optic disc | Choriocapillaris layer | RPC peripapillary VD | RPC whole VD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aly et al. [56] | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| Rogaczewska et al. [43] | – | – | – | – | – | – | – | – | – | – | – | ↓ | – | |
| Ulusoy et al. [47] | – | – | ↓ | ↓ | ↓ | ∼ | ∼ | ∼ | ↓ Inf-temp | – | ||||
| Farci et al. [52] | – | – | – | – | – | – | – | – | – | – | – | – | ∼ | |
| Lanzillo et al. [31] | – | ∼ | ∼ except in ETDRS inf | – | ∼ | – | – | – | – | – | – | – | – |
| Study (Zeiss) | FAZ area | Superficial foveal VD/PD | Superficial parafoveal VD/PD | Superficial perifoveal VD/PD | Superficial whole VD/PD | Deep fovea VD/PD | Deep parafoveal VD/PD | Deep perifoveal VD/PD | Deep whole VD/PD | Macula | Optic disc | Choriocapillaris layer | RPC peripapillary VD/PD | RPC whole VD/PD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Khader et al. [36] | – | – | – | – | ↓VD | – | – | – | ↓VD | – | ↓VD | – | – | – |
| Jiang et al. [57] | – | – | – | – | ↑VVD | – | – | – |
↓ ↑VVD |
– | – | – | – |
↓ ↑VVD |
| Study (Nidek) | FAZ area | Superficial foveal VD | Superficial parafoveal VD | Superficial perifoveal VD | Superficial whole VD | Deep fovea VD | Deep parafoveal VD | Deep perifoveal VD | Deep whole VD | Macula | Optic disc | Choriocapillaris layer | RPC peripapillary VD | RPC whole VD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yilmaz et al. [45] | ∼ | – | ↓ | ↓ | ↓ | – | ∼ | ∼ | ∼ | – | – | – | ∼ | – |
| Study (Heidelberg) | FAZ area | Superficial foveal VD | Superficial parafoveal VD | Superficial perifoveal VD | Superficial whole VD | Deep fovea VD | Deep parafoveal VD | Deep perifoveal VD | Deep whole VD | Macula | Optic disc | Choriocapillaris layer | RPC peripapillary VD | RPC whole VD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jesus et al. [51] | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Murphy et al. [22] | – | – | – | – | ↓ | – | – | – | ∼ | – | – | – | – | – |
| Murphy et al. [49] | – | – | – | – | ↓ IED | – | – | – | – | – | – | – | – | – |
| Study (Axsun) | FAZ area | Superficial foveal VD | Superficial parafoveal VD | Superficial perifoveal VD | Superficial whole VD | Deep fovea VD | Deep parafoveal VD | Deep perifoveal VD | Deep whole VD | Macula | Optic disc | Choriocapillaris layer | RPC peripapillary VD | RPC whole VD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Spain et al. [48] | – | – | – | – | – | – | – | – | – | – | ↓ Flow Index | – | – | – |
| Wang et al. [46] | – | – | ∼Flow Index | – | – | – | ∼Flow Index | – | – | – | ↓ Flow Index | – | – | – |
| Study (Topcon) | FAZ area | Superficial foveal VD | Superficial parafoveal VD | Superficial perifoveal VD | Superficial whole VD | Deep fovea VD | Deep parafoveal VD | Deep perifoveal VD | Deep whole VD | Macula | Optic disc | Choriocapillaris layer | RPC peripapillary VD | RPC whole VD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cordon et al. [53] | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
–: Data not reported
∼: No significant difference
MSON multiple sclerosis with optic neuritis, MSNON multiple sclerosis without optic neuritis, VD vessel area density, VVD volumetric vessel density, RPC radial peripapillary capillary, PD vessel perfusion density, VVD volumetric vessel density, Inf inferior quadrant, Temp temporal quadrant, Sup superior quadrant, Nasal nasal quadrant