TABLE 3.

Lymphoma emergencies

Hematologic emergency	Suggestive signs/symptoms	Initial management
Tumor lysis syndrome	Elevated lactate dehydrogenase (LDH), uric Acid, Potassium, ±phosphorus. AKI	Aggressive fluid resuscitation with isotonic fluids, management of hyperkalemia if indicated, immediate emergency room evaluation and hospitalization
Venous thromboembolism	Unilateral lower extremity swelling, erythema, pain. Sudden onset dyspnea/hypoxia.	If stable for outpatient management, low molecular weight heparin (LMWH), apixaban, rivaroxaban have the most evidence for anticoagulation in patients with malignancy
Paraneoplastic processes	Neurologic symptoms, dermatologic changes, fever, hematologic abnormalities, arthralgias, renal dysfunction, angioedema	Commensurate with the severity of presentation. Evidence of MAHA, severe neurologic involvement, rash and fever, severe AKI should be referred to the ED
Compressive or infiltrative tumor effects	Hepatic or renal dysfunction Evidence of neurovascular compromise including claudication, bowel or bladder dysfunction, saddle anesthesia, motor or sensory dysfunction.	Commensurate with the severity of presentation Severe hepatic or renal dysfunction, evidence of cauda equina syndrome, or rapidly progressive motor/sensory changes should be referred to the ED