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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Clin Exp Metastasis. 2022 Jan 12;39(3):391–406. doi: 10.1007/s10585-022-10146-x

Fig. 3. Schematic representation of CD44 expression in the context of epithelial-mesenchymal plasticity.

Fig. 3

In cancer, CD44v isoforms are associated with a more epithelial phenotype while CD44s is associated with mesenchymal characteristics. Changes in CD44 splicing lead to shifts in isoform expression during EMT and MET. These shifts in isoform expression in turn promote changes in metastatic potential and stemness characteristics. Created with BioRender.com