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. 2023 Mar 27;2023(3):CD009885. doi: 10.1002/14651858.CD009885.pub3
Database Search strategy
Cochrane Central Register of Controlled Trials (CENTRAL; Cochrane Library) #1 MeSH descriptor: [Methylphenidate] explode all trees
#2 (methylphenidate):ti,ab,kw
#3 adaphen or adhansia or addwize or aptensio or artige or attenta or biphentin or calocain or centredrin or concerta or cotempla
#4 daytrana or dexmethylphenidat* or difumenil or elmifiten or equasym or focalin or foquest or inspiral or jornay or matoride or medikid or medikinet*
#5 meridil or metadate or methyl phenidat* or methyl phenidylacetat* or methylfenid* or methylin or methylofenidan or methylphenid* or methyl phenid*
#6 methyl phenidyl acetat* or methypatch or metidate or metilfenidat* or motiron* or MPH or omzin or penid* or phenid* or phenidyl hydrochlorid* or phenidylat* or plimasin
#7 PMS‐methylphenid* or prohiper or quasym* or quilli* or relexxii or Richter Works or riphenidat* or ritalin* or rubifen or stimdat* or tifinidat or tradea or tranquilyn or tsentedrin
#8 #1 or #2 or #3 or #4 or #5 or #6 or #7
#9 MeSH descriptor: [Child] explode all trees
#10 MeSH descriptor: [Adolescent] explode all trees
#11 MeSH descriptor: [Infant] explode all trees
#12 (child* OR boy* OR girl* OR adolescen* OR teen* OR preschool OR pre school OR infant* OR baby OR babies OR toddler* OR school child* or youth*)
#13 #9 or #10 or #11 #12
#14 #8 and #13
#15 MeSH descriptor: [Attention Deficit and Disruptive Behavior Disorders] explode all trees
#16 adhd or addh or adhs or add
#17 (((attention* or behav*) near/3 (defic* or dysfunc* or disorder*))):ti,ab,kw (Word variations have been searched)
#18 ((impulsiv* or inattentiv* or inattention*)):ti,ab,kw (Word variations have been searched)
#19 MeSH descriptor: [Hyperkinesis] explode all trees
#20 (hyperkine*):ti,ab,kw (Word variations have been searched)
#21 ((minimal near/3 brain near/3 (disorder* or dysfunct* or damage*))):ti,ab,kw (Word variations have been searched)
#22 ((disrupt* near/3 disorder*) or (disrupt* near/3 behav*) or (defian* near/3 disorder*) or (defian* near/3 behav*)):ti,ab,kw (Word variations have been searched)
#23 (hyperactiv*):ti,ab,kw
#24 #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22
#25 #14 and #24
#26 MeSH descriptor: [] explode all trees and with qualifier(s): [adverse effects ‐ AE, drug effects ‐ DE, chemically induced ‐ CI]
#27 ((safe or safety or adverse or tolerability or toxicity or toxic or adrs or adr or tolerance or tolerate or harm or harms or harmful or complication* or risk or risks)):ti,ab,kw (Word variations have been searched)
#28 (side next effect*):ti,ab,kw
#29 (undesirable next effect*):ti,ab,kw (Word variations have been searched)
#30 (treatment next emergent):ti,ab,kw (Word variations have been searched)
#31 (unintended next event):ti,ab,kw (Word variations have been searched)
#32 (unintended next effect):ti,ab,kw (Word variations have been searched)
#33 #26 or #27 or #28 or #29 or #30 or #31 or #32 827410
#34 MeSH descriptor: [Mood Disorders] explode all trees
#35 (depression or depressive):ti,ab,kw (Word variations have been searched)
#36 MeSH descriptor: [Psychotic Disorders] explode all trees
#37 (psychosis or (psychotic near/4 symptom*)):ti,ab,kw (Word variations have been searched)
#38 MeSH descriptor: [Body Weight] explode all trees
#39 MeSH descriptor: [Anorexia] explode all trees
#40 ((loss or lose or losing or decreas* or reduc*) near/3 (weight or appetite)):ti,ab,kw (Word variations have been searched)
#41 ((reduc* or retard* or inhibit* or deficit*) near/4 growth):ti,ab,kw (Word variations have been searched) 5140
#42 MeSH descriptor: [Hypertension] explode all trees
#43 MeSH descriptor: [Heart Rate] explode all trees
#44 MeSH descriptor: [Tachycardia] explode all trees
#45 MeSH descriptor: [Death] explode all trees
#46 (death):ti,ab,kw (Word variations have been searched)
#47 MeSH descriptor: [Infertility] explode all trees
#48 MeSH descriptor: [Carcinogens] explode all trees
#49 ((increas* near/4 (heart rate or pulse or blood pressure))):ti,ab,kw (Word variations have been searched)
#50 ((((loss or reduc*) near/4 fertility) or infertility)):ti,ab,kw (Word variations have been searched)
#51 MeSH descriptor: [Neoplasms] explode all trees
#52 (((risk near/2 cancer) or (cytogenetic near/2 effect*))):ti,ab,kw (Word variations have been searched)
#53 #33 or #34 or #35 or #36 or #37 or #37 or #38 or #39 or #40 or #41 or #42 or #43 or #44 or #45 or #46 or #47 or #48 or #49 or #50 or #51 or #52
#54 #8 and #13 and #24
#55 #8 and #13 and #53
#56 #54 or #55 with Publication Year from 2015 to 2021, in Trials
Ovid MEDLINE 1 exp "Attention Deficit and Disruptive Behavior Disorders"/
2 adhd.mp.
3 addh.mp.
4 adhs.mp.
5 "add".mp.
6 (ad adj hd).mp. (
7 ((attention* or behav*) adj3 (defic* or dysfunc* or disorder*)).mp.
8 ((disrupt* adj3 disorder*) or (disrupt* adj3 behav*) or (defian* adj3 disorder*) or (defian* adj3 behav*)).mp.
9 (impulsiv* or inattentiv* or inattention*).mp.
10 hyperactiv*.mp.
11 hyperkinesis*.mp.
12 exp Hyperkinesis/
13 (minimal adj brain adj3 disorder*).mp.
14 (minimal adj brain adj3 dysfunction*).mp.
15 (minimal adj brain adj3 damage*).mp.
16 or/1‐15
17 randomized controlled trial.pt.
18 controlled clinical trial.pt.
19 randomized controlled trials.mp.
20 exp Randomized Controlled Trial/
21 random allocation.mp. or Random Allocation/
22 double blind method.mp.
23 single blind method.mp.
24 clinical trial.pt.
25 (clin* adj25 trial*).ab,ti.
26 ((singl* or doubl* or tripl* or trebl*) adj25 (blind* or mask* or dumm*)).mp.
27 exp Clinical Trial/
28 placebos.mp.
29 "placebo*".ab,ti.
30 "random*".ab,ti.
31 comparative study.mp.
32 comparative trial.mp.
33 Evaluation Studies as Topic/
34 exp Clinical Trials as Topic/
35 follow up studies.mp.
36 prospective studies.mp.
37 (control* or prospectiv* or volunteer*).ab,ti.
38 or/17‐37
39 methylphenidate.mp. or exp Methylphenidate/
40 adaphen.mp.
41 adhansia.mp.
42 addwize.mp.
43 aptensio.mp.
44 artige.mp.
45 attenta.mp.
46 biphentin.mp.
47 calocain.mp.
48 centedrin*.mp.
49 concerta*.mp.
50 cotempla.mp.
51 daytrana.mp.
52 dexmethylphenidat*.mp.
53 difumenil.mp.
54 elmifiten.mp.
55 equasym*.mp.
56 elmifiten*.mp.
57 focalin.mp.
58 focalin*.mp.
59 foquest.mp.
60 inspiral.mp.
61 jornay.mp.
62 matoride.mp.
63 medikid.mp.
64 medikinet*.mp.
65 meridil.mp.
66 metadate*.mp.
67 methyl phenidat*.mp.
68 methyl phenid*.mp.
69 methyl phenidylacetat*.mp.
70 methylfenid*.mp.
71 methylin*.mp.
72 methylofenid*.mp.
73 methylphenid*.mp.
74 methyl phenid*.mp.
75 methypatch.mp.
76 metidate.mp.
77 metilfenidat*.mp.
78 motiron*.mp.
79 MPH.mp.
80 omozin*.mp.
81 penid*.mp.
82 phenida.mp.
83 phenidyl hydrochlorid*.mp.
84 phenidylat*.mp.
85 phenidyl*.mp.
86 plimasin*.mp.
87 PMS‐methylphenid*.mp.
88 prohiper.mp.
89 quazym*.mp.
90 quilli*.mp.
91 relexxii.mp.
92 Richter Works.mp.
93 riphenidat*.mp.
94 ritalin*.mp.
95 rubifen*.mp.
96 stimdat*.mp.
97 tifinidat*.mp.
98 tradea.mp.
99 tranquilyn.mp.
100 tsentedrin*.mp.
101 or/39‐100
102 exp Child/
103 exp Adolescent/
104 exp Infant/
105 (child* or boy* or girl* or adolescen* or teen* or preschool* or pre school or infant* or baby or babies or
toddler* or school child* or youth* or young).mp.
106 or/102‐105
107 16 and 38 and 101 and 106
108 (ae or co or de).fs.
109 (((safe or safety or (side adj1 effect*) or undesirable) adj1 effect*) or (treatment adj1 emergent) or
tolerability or tolerance or tolerate or toxicity or toxic or adrs or adr or harm or harms or harmful or complication* or risk or risks or (unintended adj1 event*)).mp. or (un‐intendend adj1 effect*).ab,ti.
110 (adverse adj2 (effect or effects or reaction or reactions or event or events or outcome or outcomes)).ab,ti.
111 Methylphenidate/ae, po, to
112 exp Mood Disorders/
113 (depression or depressive).ab,ti.
114 exp Psychotic Disorders/
115 (psychosis or (psychotic adj4 symptom*)).ab,ti.
116 exp body weight/ or anorexia/
117 ((loss or lose or losing or reduc*) adj3 (weight or appetite)).ab,ti.
118 ((reduc* or retard* or inhibit* or deficit*) adj4 growth).ab,ti.
119 exp Hypertension/
120 Heart Rate/
121 Tachycardia/
122 (increas* adj4 (heart rate or pulse or blood pressure)).ab,ti.
123 exp Death, Sudden/
124 death.ab,ti.
125 exp Infertility/
126 (((loss or reduc*) adj4 fertility) or infertility).ab,ti.
127 exp Carcinogens/
128 exp Neoplasms/
129 ((risk adj2 cancer) or (cytogenic adj2 effect*)).ab,ti.
130 or/108‐129
131 38 and 101 and 106 and 130
132 107 or 131
133 101 and 106 and 130
134 16 and 101 and 106 and 38
135 131 or 134
136 limit 135 to yr="2015 ‐Current"
Embase (Ovid) 1 exp attention deficit disorder/
2 adhd.ti,ab.
3 addh.ti,ab.
4 ADHS.ti,ab.
5 (ad adj HD).ti,ab.
6 "(ADD)".mp.
7 ((disrupt* adj3 disorder*) or (disrupt* adj3 behav*) or (defian* adj3 disorder*) or (defian* adj3 behav*)).ti,ab.
8 ((attention* or behav*) adj3 (defic* or dysfunc* or disorder*)).ti,ab.
9 (impulsiv* or inattentiv* or inattention*).ti,ab.
10 exp hyperactivity/
11 hyperkinesia/
12 "hyperactiv*".ti,ab.
13 "hyperkinesis*".ti,ab.
14 (minimal adj brain adj3 disorder*).ti,ab.
15 (minimal adj brain adj3 dysfunction*).ti,ab.
16 (minimal adj brain adj3 damage*).ti,ab.
17 or/1‐16
18 exp methylphenidate/ or methylphenidate.mp.
19 adaphen.mp.
20 adhansia.mp.
21 addwize.mp.
22 aptensio.mp.
23 artige.mp.
24 attenta.mp.
25 biphentin*.mp.
26 calocain.mp.
27 centedrin*.mp.
28 concerta*.mp.
29 cotempla.mp.
30 daytrana.mp.
31 dexmethylphenidat*.mp.
32 difumenil*.mp.
33 elmifiten*.mp.
34 equasym.mp.
35 focalin*.mp.
36 foquest.mp.
37 inspiral.mp.
38 jornay.mp.
39 matoride.mp.
40 medikid.mp.
41 medikinet*.mp.
42 meridil.mp.
43 metadate.mp.
44 methyl phenidat*.mp.
45 methyl phenidylacetat*.mp.
46 methylfenid*.mp.
47 methylin*.mp.
48 methylofenid*.mp.
49 methylphenid*.mp.
50 methyl phenidyl acetat*.mp.
51 methypatch.mp.
52 metidate.mp.
53 metilfenidat*.mp.
54 motiron.mp.
55 MPH.mp.
56 omozin*.mp.
57 penid*.mp.
58 phenidyl hydrochlorid.mp.
59 phenidyl hydrochlorid*.mp.
60 phenidyl*.mp.
61 plimasin*.mp.
62 PMS‐methylphenid*.mp.
63 quasym.mp.
64 quilli*.mp.
65 relexxii.mp.
66 Richter Works.mp.
67 riphenidat*.mp.
68 ritalin*.mp.
69 rubifen*.mp.
70 stimdat*.mp.
71 tifinidat*.mp.
72 tradea.mp.
73 tranquilyn.mp.
74 tsentedrin*.mp.
75 or/18‐62
76 exp child/
77 exp adolescent/
78 exp juvenile/
79 exp infant/
80 (child* or boy* or girl* or adolescen* or teen* or preschool or pre school or infant* or baby or babies or toddler* or school child* or young or youth*).mp.
81 76 or 77 or 78 or 79 or 80
82 clinical trial/
83 randomized controlled trial/
84 randomization/
85 single blind procedure/
86 double blind procedure/
87 crossover procedure/
88 placebo/
89 prospective study/
90 (randomi?ed controlled adj1 trial*).ti,tw.
91 rct.ti,tw.
92 randomly allocated.ti,tw.
93 allocated randomly.ti,tw.
94 random allocation.ti,tw.
95 (allocated adj2 random).ti,tw.
96 (single adj1 blind*).ti,tw.
97 (double adj1 blind*).ti,tw.
98 ((treble or triple) adj1 blind*).ti,tw.
99 "placebo*".ti,tw.
100 or/82‐99
101 17 and 75 and 81 and 100
102 (safe or safety or (side adj1 effect*) or (undesirable adj1 effect*) or (treatment adj1 emergent) or
tolerability or tolerance or tolerate or toxicity or toxic or adrs or adr or harm or harms or harmful or complication* or risk or risks or (unintended adj1 event*) or (un‐intended adj1 effect*)).ab,ti.
103 (adverse adj2 (effect or effects or reaction or reactions or event or events or outcome or outcomes)).ab,ti.
104 exp adverse drug reaction/
105 exp side effect/
106 methylphenidate/ae, to [Adverse Drug Reaction, Drug Toxicity]
107 exp mood disorder/si [Side Effect]
108 (depression or depressive).ab,ti.
109 exp psychosis/si [Side Effect]
110 (psychosis or (psychotic adj4 symptom*)).ab,ti.
111 growth retardation/
112 growth inhibition/
113 ((loss or lose or losing or reduc*) adj3 (weight or appetite)).ab,ti.
114 ((reduc* or retard* or inhibit* or deficit*) adj4 growth).ab,ti.
115 hypertension/si [Side Effect]
116 heart rate/
117 cardiovascular effect/
118 tachycardia/si [Side Effect]
119 (increas* adj4 (heart rate or pulse or blood pressure)).ab,ti. (68994)
120 sudden death/
121 death.ab,ti.
122 infertility/si [Side Effect]
123 (((loss or reduc*) adj4 fertility) or infertility).ab,ti.
124 cancer risk/
125 drug carcinogenicity/ or carcinogenicity/
126 chromosome aberration/si [Side Effect]
127 childhood cancer/si [Side Effect]
128 ((risk adj2 cancer) or (cytogenic adj2 effect*)).ab,ti.
129 or/102‐128
130 75 and 81 and 100 and 129
131 101 or 130
132 limit 131 to yr="2015 ‐Current"
CINAHL (Cumulative Index to Nursing and Allied Health Literature; EBSCOhost) S1 (MH "Methylphenidate")
S2 AB methylphenidate
S3 TI methylphenidate
S4 S2 OR S3
S5 TI ( adaphen or adhansia or addwize or aptensio or artige or attenta or biphentin ) OR AB ( adaphen or adhansia or addwize or aptensio or artige or attenta or biphentin )
S6 TI ( calocain or centedrin or concerta or cotempla or daytrana or dexmethylphenidat* or difumenil or elmifiten or equasym or focalin or foquest or inspiral or jornay or motoride ord medikid or medikinet* ) OR AB ( calocain or centedrin or concerta or cotempla or daytrana or dexmethylphenidat* or difumenil or elmifiten or equasym or focalin or foquest or inspiral or jornay or motoride ord medikid or medikinet* )
S7 TI ( meridil or metadate or methyl phenidat or methyl phenidylacetat* or methylphenid* or methylfenid* or methylin or methylofenidan or methylphenid* or methyl phenid* ) OR AB ( meridil or metadate or methyl phenidat or methyl phenidylacetat* or methylphenid* or methylfenid* or methylin or methylofenidan or methylphenid* or methyl phenid* )
S8 TI ( methylphenidyl acetat* or methypatch or metidate or metilfenidat* or motiron* or MPH or omzin* or penid* or phenid* or phenidyl hydrochlorid* or phenidylat* or plimasin* ) OR AB ( methylphenidyl acetat* or methypatch or metidate or metilfenidat* or motiron* or MPH or omzin* or penid* or phenid* or phenidyl hydrochlorid* or phenidylat* or plimasin* )
S9 TI ( PMS‐methylphenid* or prohiper or quasym* or quilli* or relexxii or Richter Works or riphenidat* or ritalin* or rubifen or stimdat* or tifinidat or tradea or tranquilyn or tsentedrin ) OR AB ( PMS‐methylphenid* or prohiper or quasym* or quilli* or relexxii or Richter Works or riphenidat* or ritalin* or rubifen or stimdat* or tifinidat or tradea or tranquilyn or tsentedrin )
S10 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9
S11 (MH "Child+") OR (MH "Infant+") OR (MH "Adolescence+")
S12 TI ( (child* OR boy* OR girl* OR adolescen* OR teen* OR preschool OR pre school OR infant* OR baby OR babies OR toddler* OR school child* or youth*) ) OR AB ( (child* OR boy* OR girl* OR adolescen* OR teen* OR preschool OR pre school OR infant* OR baby OR babies OR toddler* OR school child* or youth*) )
S13 S11 OR S12
S14 S10 AND S13
S15 (MH "Randomized Controlled Trials+") OR (MH "Double‐Blind Studies") OR (MH "Single‐Blind Studies") OR (MH "Random Assignment") OR (MH "Pretest‐Posttest Design+") OR (MH "Cluster Sample+")
S16 TI randomised or randomized
S17 AB random*
S18 TI trial
S19 (MH "Sample Size") AND AB ( assigned or allocated or control )
S20 (MH "Placebos")
S21 PT Randomized Controlled Trials
S22 PT randomized controlled trial
S23 AB control W5 group
S24 (MH "Crossover Design") OR (MH "Comparative Studies+")
S25 AB cluster W3 RCT
S26 (MH "Animals+")
S27 (MH "Animal Studies")
S28 TI animal model*
S29 S26 OR S27 OR S28
S30 (MH "Human")
S31 S29 NOT S30
S32 S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25
S33 S32 NOT S31
S34 S14 AND S33
S35 S14 AND S33
PsycINFO (Ovid) 1 exp Attention Deficit Disorder/
2 adhd.ab,ti.
3 addh.ab,ti.
4 ADHS.ab,ti.
5 (AD adj HD).ab,ti.
6 "ADD".ab,ti.
7 ((attention* or behav*) adj3 (defic* or dysfunc* or disorder*)).ab,ti.
8 ((disrupt* adj3 disorder*) or (disrupt* adj3 behav*) or (defian* adj3 disorder*) or (defian* adj3 behav*)).ab,ti.
9 (impulsiv* or inattentiv* or inattention*).ab,ti.
10 "hyperactiv*".ab,ti.
11 hyperkinesis.ab,ti.
12 exp HYPERKINESIS/
13 (minimal adj brain adj3 disorder*).ab,ti.
14 (minimal adj brain adj3 dysfunction*).ab,ti.
15 (minimal adj brain adj3 damage*).ab,ti.
16 or/1‐15
17 exp Treatment Effectiveness Evaluation/
18 exp "Treatment outcomes"/
19 Placebo/
20 Followup Studies/
21 placebo*.ab,ti.
22 random*.ab,ti.
23 comparative stud*.ab,ti.
24 (clinical adj3 trial*).ab,ti.
25 (research adj3 design).ab,ti.
26 (evaluat* adj3 stud*).ab,ti.
27 (prospectiv* adj3 stud*).ab,ti.
28 ((singl* or doubl* or trebl* or tripl*) adj3 (blind* or mask*)).ab,ti.
29 or/17‐28
30 methylphenidate.mp. or exp METHYLPHENIDATE/
31 adaphen.mp.
32 adhansia.mp.
33 addwize.mp.
34 aptensio.mp.
35 artige.mp.
36 attenta.mp.
37 biphentin.mp.
38 calocain.mp.
39 centedrin.mp.
40 concerta.mp.
41 cotempla.mp.
42 daytrana.mp.
43 dexmethylphenidat*.mp.
44 difumenil.mp.
45 elmifiten.mp.
46 equasym*.mp.
47 focalin*.mp.
48 foquest.mp.
49 inspiral.mp.
50 jornay.mp.
51 matoride.mp.
52 medikid.mp.
53 medikinet*.mp.
54 meridil.mp.
55 metadate*.mp.
56 methyl phenidat*.mp.
57 methyl phenidylacetat*.mp.
58 methylfenid*.mp.
59 methylin.mp.
60 methylofenidan.mp.
61 methylphenid*.mp.
62 methyl phenid*.mp.
63 methyl phenidyl acetat*.mp.
64 methypatch.mp.
65 metidate.mp.
66 metilfenidat*.mp.
67 motiron*.mp.
68 MPH.mp.
69 omozin.mp.
70 penid*.mp.
71 phenid*.mp.
72 phenidyl hydrochlorid*.mp.
73 phenidylat*.mp.
74 plimasin*.mp.
75 PMS‐methylphenid*.mp.
76 prohiper.mp.
77 quasym*.mp.
78 quilli*.mp.
79 relexxii.mp.
80 Richter works.mp.
81 riphenidat*.mp.
82 ritalin*.mp.
83 rubifen.mp.
84 stimdat*.mp.
85 tifinidat.mp.
86 tradea.mp.
87 tranquilyn.mp.
88 tsentedrin*.mp.
89 or/30‐88
90 (child* or boy* or girl* or adolescen* or teen* or preschool or pre school or infant* or baby or babies or
toddler* or school child* or young or youth*).ab,ti.
91 16 and 29 and 89 and 90
92 exp "Side Effects (Drug)"/
93 (safe or safety or (side adj1 effect*) or (undesirable adj1 effect*) or (treatment adj1 emergent) or tolerability
or tolerance or tolerate or toxicity or toxic or adrs or adr or harm or harms or harmful or complication* or risk or risks or (unintended adj1 event*) or (un‐intended adj1 effect*)).ab,ti.
94 (adverse adj2 (effect or effects or reaction or reactions or event or events or outcome or outcomes)).ab,ti.
95 92 or 93 or 94
96 exp Major Depression/
97 exp Affective Disorders/
98 (depression or depressive).ab,ti.
99 exp Psychosis/
100 (psychosis or (psychotic adj4 symptom*)).ab,ti.
101 exp Body Weight/
102 exp Appetite Depressing Drugs/
103 exp Appetite/
104 ((loss or lose or losing or reduc*) adj3 (weight or appetite)).mp. [mp=title, abstract, heading word, table of
contents, key concepts, original title, tests & measures, mesh]
105 ((reduc* or retard* or inhibit* or deficit*) adj4 growth).ab,ti.
106 exp Cardiovascular Disorders/
107 exp Heart Rate/
108 exp Heart Rate Affecting Drugs/
109 (increas* adj4 (heart rate or pulse or blood pressure)).ab,ti.
110 exp "Death and Dying"/
111 death.ab,ti.
112 exp Infertility/
113 exp Fertility/
114 (((loss or reduc*) adj4 fertility) or infertility).ab,ti.
115 exp Neoplasms/
116 exp Carcinogens/
117 ((risk adj2 cancer) or (cytogenic adj2 effect*)).ab,ti.
118 or/96‐117
119 29 and 89 and 90 and 118
120 91 or 119
121 limit 120 to yr="2015 ‐Current"
Epistemonikos searched with a simple search:
(title:((title:(attention deficit OR adhd OR hyperactivity OR hypekinetic) OR abstract:(attention deficit OR adhd OR hyperactivity OR hypekinetic))
AND (title:(methylphenidate OR ritalin OR MPH) OR abstract:(methylphenidate OR ritalin OR MPH))
AND ((title:children OR child OR young OR youth OR adolescent) OR abstract:(children OR child OR young OR youth OR adolescent)))
2015‐2021
Combined with search for ten published reviews where all included studies for each review where downloaded if possible.
1. Catala‐Lopez F, Hutton B, Nunez‐Beltran A, et al. The pharmacological and non‐pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review with network meta‐analyses of randomised trials. PLOS ONE 2017;12:e0180355. doi: 10.1371/journal.pone.0180355
2. Cerrillo‐Urbina AJ, Garcia‐Hermoso A, Pardo‐Guijarro MJ, et al. The effects of long‐acting stimulant and nonstimulant medications in children and adolescents with attention‐deficit/hyperactivity disorder: A meta‐analysis of randomized controlled trials. J Child Adolesc Psychopharmacol 2018;28:494‐507. doi: 10.1089/cap.2017.0151
3. Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention‐deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta‐analysis. Lancet Psychiatry 2018;5:727‐38. doi: 10.1016/s2215‐0366(18)30269‐4
4. Holmskov M, Storebø OJ, Moreira‐Maia CR, et al. Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta‐analysis and Trial Sequential Analysis of randomised clinical trials. PLOS ONE 2017;12:e0178187. doi: 10.1371/journal.pone.0178187
5. Kemper AR, Maslow GR, Hill S, et al. AHRQ Comparative Effectiveness Reviews Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 [Available from: Available from: https://www.ncbi.nlm.nih.gov/books/NBK487761/.
6. Liu H, Feng W, Zhang D. Association of ADHD medications with the risk of cardiovascular diseases: a meta‐analysis. Eur Child Adolesc Psychiatry 2019;28:1283‐93. doi: 10.1007/s00787‐018‐1217‐x
7. Osland ST, Steeves TD, Pringsheim T. Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders. Cochrane Database Syst Rev 2018;6:Cd007990. doi: 10.1002/14651858.CD007990.pub3
8. Punja S, Xu D, Schmid CH, et al. N‐of‐1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta‐analysis. J Clin Epidemiol 2016;76:65‐75. doi: 10.1016/j.jclinepi.2016.03.026
9. Ramstad E, Storebø OJ, Gerner T, et al. Hallucinations and other psychotic symptoms in response to methylphenidate in children and adolescents with attention‐deficit/hyperactivity disorder: a Cochrane systematic review with meta‐analysis and trial sequential analysis. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology 2018;6(1):52‐71. doi: https://doi.org/10.21307/sjcapp‐2018‐003
10. Solmi M, Fornaro M, Ostinelli EG, et al. Safety of 80 antidepressants, antipsychotics, anti‐attention‐deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta‐review of 78 adverse effects. World Psychiatry 2020;19(2):214‐32. doi: https://doi.org/10.1002/wps.20765
CPCI‐S (Conference Proceedings Citation Index ‐ Science); CPCI‐SSH (Conference Proceedings Citation Index ‐ Social Science & Humanities)
(Web of Science)		 #2 AND #1
#2 TS=(child* or boy* or girl* or adolescen* or teen* or preschool* or "pre school*" or infant* or baby or babies or toddler* or "school child*" or schoolchild* or youth*)
#1 TS=(Methylphenidate or Attenta or Biphentin or Calocain or Centedrin* or Concerta or Daytrana or Dexmethylphenidat* or Elmifiten or Equasym or Focalin or Medikid or Medikinet or Meridil or Metadate or "Methyl phenidat*" or "Methyl phenidylacetat" or Methylfenid or Methylin or Methylofenidan or Methylphenid* or "Methyl phenidyl acetat*" or Methypatch or Metilfenidato or Motiron or MPH or Penid or Omozin or Quazym or "Phenidyl hydrochlorid*" or Phenidylat* or Plimasin* or "PMS‐Methylphenid* " or "Richter Works" or Riphenidat* or Ritalin* or Rubifen or Stimdat* or Tifinidat or Tranquilyn or Tsentedrin*)
ClinicalTrials.gov Advanced search: Methylphenidate OR concerta OR daytrana OR dexmethylphenidate OR equasym OR focalin OR medikinet OR MPH OR Ritalin
Studies with results
Age group: Child
Studies With Results | Methylphenidate OR concerta OR daytrana OR dexmethylphenidate OR equasym OR focalin OR medikinet OR MPH OR Ritalin | Child
Applied Filters: With Results Child (birth–17)
WHO ICTRP (World Health Organisation International Clinical Trials Registry Platform; who.int/ictrp/en) Methylphenidate OR concerta OR daytrana OR dexmethylphenidate OR equasym OR focalin OR medikinet OR MPH OR Ritalin
Children
NDLTD (Networked Digital Library of Theses and Dissertations; ndltd.org/) methylphenidate AND child* AND (attention deficit or hyperactiv*)
DART‐Europe E‐theses Portal (https://www.dart-europe.org/basic-search.php) methylphenidate AND child*
Thesis Canada (https://library-archives.canada.ca/eng/services/services-libraries/theses/Pages/theses-canada.aspx) methylphenidate
Worldcat (https://www.worldcat.org/search?q=methylphenidate) methylphenidate