EUCTR2008‐001291‐71‐DE.

Study name	Public title: not reported Scientific title: Electrophysiological correlates of putative endophenotypes of attention‐deficit/hyperactivity disorder (ADHD)
Methods	Single‐blind, randomised controlled, parallel‐group trial Study duration: 3 years
Participants	Sample size (target): 120 Inclusion criteria Aged 10‐50 years DSM‐IV criteria of ADHD must be met (during childhood and actual) Exclusion criteria Significant psychiatric axis‐I comorbidities (bipolar disorder, psychosis, depression, drug addiction) Suicidal tendencies Epilepsy Metal parts in the head, heart pacemakers Pregnancy Severe medical comorbidities (cardiovascular or cerebrovascular illnesses, liver and kidney diseases hyperthyreosis) Pre‐treatment with MPH or atomoxetine Known incompatibility of MPH or atomoxetine Intake of MAOIs within the last 14 days prior to pharmacological challenge Actual treatment with other psychiatric medications
Interventions	Atomoxetine hydrochloride 10 mg MPH 10 mg Placebo
Outcomes	Non‐serious AEs Neurophysiological measures (instrument not reported) Timing of outcome assessment not reported
Starting date	23 July 2008 (date of registration). Starting date not reported
Contact information	Not available
Notes	Sponsor: University of Wuerzburg Declaration of interest: not reported