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. 2023 Mar 27;10(3):e200103. doi: 10.1212/NXI.0000000000200103

Figure 1. Identifying LGI1 Peptides With Predicted High Binding Affinity for Selected HLAs.

Figure 1

(A) Binding likelihood of peptides within epitempin repeat (EPTP) and leucine-rich repeat (LRR) domains to HLA-DQ and HLA-DR molecules. Dashed lines mark the absolute value of the rank binding probability cutoff (=1), where all peptides above the dashed line are ranked strong binders. The likelihood binding was determined by 1-log10(rank). (B) Heatmap of binding affinity of peptides (represented by positions) predicted by NetMHCIIpan4.1 to bind the selected HLAs (high = rank <1, medium = rank 1–3, and low = rank >3). LGI1 = leucine-rich glioma-inactivated 1.