Perez‐Tortosa 2015.

Methods	Setting: 43 primary care teams, Spain Recruitment: diabetic patients during visits, or were selected by simple random sampling from a list of diabetic smokers. Not selected for motivation
Participants	948 (after exclusion of 129 without recorded baseline stage of change, not included in analyses) diabetic smokers (any smoking in past 7 days at recruitment) (Aged over 14 but predominantly adults). 24% F, av. age 60, av. cpd 15 Provider: primary care teams
Interventions	1. Usual care 2. Intensive, individualized intervention using motivational interview, therapies & medications based on stage of change. Up to 8 visits over 12 months for those in preparation/action stages. Median visits 4 (2‐6), contact time 100 mins
Outcomes	Abstinence: continued abstinence at 1 year Validation: CO level of less than 6 ppm
Notes	New for 2015 update No details of how many people used medications or what type, coded as moderate treatment take‐up
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Cluster randomized by primary care centre
Allocation concealment (selection bias)	High risk	‘Patients were recruited as they visited the primary care team or alternatively were selected by simple random sampling from a list of diabetic smokers’. Patients recruited after centres allocated, and baseline differences, so judged at high risk for selection bias
Incomplete outcome data (attrition bias) All outcomes	High risk	129 without baseline stage of change data were excluded from analyses. Loss to follow‐up 24% (111) I, 23.4% (115) C, not included in reported analyses, reincluded in denominators for this MA.