Rodriguez 2003.

Methods	Setting: 3 worksites, Spain. Recruitment: at annual medical check‐up, motivated to quit smoking
Participants	218 smokers; 86% M, av. age 43 Provider: occupational physician
Interventions	1. Intervention: 5‐8 mins structured counselling + further contacts at 2 days, 15 days & 3m. NRT based on Fagerstrom score; < 5 counselling only; 5‐7 8 wks x14 mg nicotine patch; > 7 4 wks x 21 mg, 4wks x 14mg, 4wks x 7mg. Could be increased if necessary. 2. Control: minimal (30‐60 secs) sporadic unstructured advice, usually at annual medical check up
Outcomes	Continuous abstinence (7 day PP at each assessment) at 12m. Validation: expired CO <= 10 ppm at each assessment
Notes	Control group participants also contacted at 2 & 15 days and most appear to have also made quit attempts. Classified as moderate treatment take‐up
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomisation
Allocation concealment (selection bias)	Low risk	Numbered sealed opaque envelopes, opened after enrolment
Incomplete outcome data (attrition bias) All outcomes	Low risk	1 death in intervention group excluded from denominator, no other reported losses to follow‐up