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. 2023 Jan 31;324(4):L413–L432. doi: 10.1152/ajplung.00282.2022

Table 1.

List of 51 proteins of rat L2 cells that were increased significantly 24 h post-S1

Statistics
Metacore Definitions
UniProtKB Name UniProt ID Entrez ID Network ID Sam t-Test (P Value) Fold Δ (S1/C) Object Type Fig. 1 Fig. 5
Protein diaphanous homolog 1 O60610 1729 DIA1 2.67 0.00548 3.4 Generic binding protein X X
Structural maintenance of chromosomes protein 3 Q9UQE7 9126 SMC3 1.18 0.02235 3.2 Generic binding protein X
Leukotriene A-4 hydrolase P09960 4048 LTA4H 1.42 0.01370 3.2 Generic enzyme
ATP-citrate synthase P53396 47 ACLY 1.57 0.00275 3.0 Generic enzyme X
C-Jun-amino-terminal kinase-interacting protein 4 O60271 9043 SPAG9 1.82 0.00251 2.7 Generic binding protein
Splicing factor 3 A subunit 1 Q15459 10291 SF3A1 1.00 0.03406 2.7 Generic binding protein X
Alcohol dehydrogenase [NADP(+)] P14550 10327 ALDX 0.79 0.05316 2.7 Generic enzyme
Poly(rC)-binding protein 1 Q15365 5093 PCBP-1 1.55 0.00584 2.5 Generic binding protein X X
Vacuolar protein sorting-associated protein 26 A O75436 9559 Vps26A 1.16 0.08734 2.5 Generic binding protein X
α-Crystallin B chain P02511 1410 α Crystallin B 1.32 0.00562 2.4 Generic binding protein X
Dopamine receptor interacting protein 4 Q4W4Y1 1.12 0.03228 2.3
Rab GDP dissociation inhibitor α P31150 2664 RABGDIA 1.64 0.01578 2.3 Regulators (GDI, GAP, GEF) X X
Protein DJ-1 K7ELW0 11315 DJ-1 0.98 0.01989 2.2 Generic enzyme X
ATP-binding cassette subfamily E member 1 P61221 6059 RLI 1.35 0.00696 2.2 Generic binding protein X
Galectin-1 P09382 3956 Galectin-1 0.81 0.07362 2.2 Receptor ligand
Exportin-2 P55060 1434 CSE1L 1.18 0.00793 2.2 Transporter X
Phosphoglycerate kinase 1 P00558 5230 PGK1 1.93 0.00097 2.2 Generic kinase X X
Protein FAM49B Q9NUQ9 51571 FAM49B 0.95 0.07184 2.1 Protein X
S-phase kinase-associated protein 1 P63208 6500 SKP1 0.85 0.06385 2.1 Generic binding protein
Adapter molecule crk P46108 1398 CRK 1.19 0.00888 2.1 Generic binding protein
Similar to 60S ribosomal protein L7 O95036 2.11 0.00063 2.1 X
Vinculin P18206 7414 Vinculin 1.33 0.00801 2.0 Generic binding protein X
Heat shock protein β-1 P04792 3315 HSP27 0.79 0.07920 2.0 Generic binding protein X
Rab GDP dissociation inhibitor β P50395 2665 GDI2 0.81 0.05170 2.0 Generic binding protein X
Ephrin type-A receptor 2 P29317 1969 Ephrin-A receptor 2 0.84 0.04238 2.0 Receptor with enzyme activity X
Transgelin-2 P37802 8407 TAGLN2 1.02 0.02116 2.0 Protein
Proteasome subunit β type-5 P28074 5693 PSMB5 0.91 0.03810 2.0 Generic protease
S-methyl-5′-thioadenosine phosphorylase Q13126 4507 MTAP 0.77 0.04806 2.0 Generic enzyme
Golgin subfamily A member 3 Q08378 2802 Golgin-160 1.11 0.05072 1.9 Generic binding protein X
Regulator of nonsense transcripts 1 Q92900 5976 RENT1 0.79 0.04820 1.9 Generic binding protein X
26S proteasome non-ATPase regulatory subunit 12 O00232 5718 PSMD12 1.33 0.01118 1.9 Generic binding protein X
Fructose-bisphosphate aldolase C P09972 230 ALDOC 1.50 0.01419 1.8 Generic enzyme X X
Pyruvate dehydrogenase E1 component subunit β P11177 5162 PDH 0.82 0.03006 1.8 Generic enzyme X
60S ribosomal protein L6 Q02878 6128 RPL6 0.98 0.01818 1.8 Generic binding protein X
Peroxiredoxin-6 P30041 9588 NSGPeroxidase 0.74 0.04281 1.8 Generic phospholipase
COP9 signalosome complex subunit 4 Q9BT78 51138 COPS4 0.81 0.04235 1.8 Generic binding protein X
Heat shock 70 kDa protein 4 P34932 3308 HSP70 0.95 0.02048 1.7 Generic binding protein X
Peptidyl-prolyl cis-trans isomerase D Q08752 5481 PPID 0.83 0.05670 1.7 Generic enzyme
40S ribosomal protein S26 P62854 6231 RPS26 0.95 0.02206 1.7 Generic binding protein X
Heat shock protein 105 kDa Q92598 10808 HSP105 0.90 0.06162 1.7 Generic binding protein X
Drug-sensitive protein 1 Q9NZ23 1.77 0.00557 1.7 X
Desmoplakin P15924 1832 Desmoplakin 1.33 0.01192 1.7 Generic binding protein X
Actin-related protein 2/3 complex subunit 4 P59998 10093 ARPC4 0.97 0.03172 1.7 Generic binding protein
Transcription elongation factor B polypeptide 2 Q15370 6923 Elongin B 0.84 0.08657 1.6 Generic binding protein X
Proteasome subunit α type-4 P25789 5685 PSMA4 0.94 0.04583 1.6 Generic protease
Elongation factor 1-α 1 P68104 1915 eEF1A 0.86 0.02515 1.6 Generic binding protein X
Plectin Q15149 5339 Plectin 1 0.94 0.01884 1.5 Generic binding protein X
Tubulin β-2A chain Q13885 7280 Tubulin β 1.86 0.00221 1.5 Generic binding protein X
Kinesin-1 heavy chain P33176 3799 KIF5B 0.78 0.03425 1.5 Generic binding protein X
60S ribosomal protein L5 P46777 6125 RPL5 1.07 0.02048 1.5 Generic binding protein X X

X denotes whether a protein was included in the indicated analysis and whether its increase by S1 (Fig. 1) was prevented by pretreatment of L2 with HMW-HA (Fig. 5). HA, hyaluronan (hyaluronic acid); HMW, high molecular weight.