Table 2.
List of 48 proteins of rat L2 cells that were significantly decreased 24 h post-S1
| Statistics |
Metacore Definition |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB Name | UniProt ID | Entrez ID | Network ID | SAM | t Test (P Value) | Fold Δ (S1/C) | Object Type | Fig. 1 | Fig. 5 |
| Trifunctional enzyme subunit α, mitochondrial | P40939 | 3030 | HADHA | 1.18 | 0.06945 | −4.6 | Generic enzyme | X | |
| Basement membrane-specific heparan sulfate proteoglycan core protein | P98160 | 3339 | Perlecan | 1.54 | 0.00765 | −3.7 | Generic binding protein | X | |
| Nuclear mitotic apparatus protein 1 | Q14980 | 4926 | NUMA1 | 1.99 | 0.00737 | −3.2 | Generic binding protein | ||
| Signal recognition particle 54 kDa protein | P61011 | 6729 | SRP54 | 1.26 | 0.04139 | −3.0 | Generic binding protein | X | |
| Ras-related protein Rab-5B | P61020 | 5869 | RAB-5B | 0.97 | 0.02599 | −2.8 | RAS - superfamily | X | X |
| Clathrin light chain A | P09496 | 1211 | Clathrin light chain | 0.96 | 0.04513 | −2.6 | Generic binding protein | ||
| NAD-dependent malic enzyme, mitochondrial | P23368 | 4200 | ME2 | 0.86 | 0.03056 | −2.4 | Generic enzyme | ||
| Glycerol-3-phosphate dehydrogenase, mitochondrial | P43304 | 2820 | GPD2 | 1.33 | 0.01184 | −2.3 | Generic enzyme | ||
| Pyridoxal-dependent decarboxylase domain-containing protein 1 | Q6P996 | 23042 | LP8165 | 1.42 | 0.03052 | −2.3 | Generic binding protein | X | |
| Heterogeneous nuclear ribonucleoprotein M | P52272 | 4670 | hnRNP M | 1.36 | 0.00843 | −2.3 | Generic binding protein | X | |
| Prostacyclin synthase | Q16647 | 5740 | PTGIS | 0.88 | 0.04089 | −2.3 | Generic enzyme | X | |
| Tumor protein D54 | O43399 | 7165 | D54 | 1.16 | 0.01435 | −2.3 | Generic binding protein | X | X |
| Nucleobindin-1 | Q02818 | 4924 | Nucb1 | 0.98 | 0.03256 | −2.3 | Generic binding protein | ||
| Vacuolar protein sorting-associated protein 13 A | Q96RL7 | 23230 | VPS13A | 1.28 | 0.04082 | −2.3 | Transporter | X | |
| Cleavage and polyadenylation specificity factor subunit 5 | O43809 | 11051 | CPSF5 | 1.02 | 0.03985 | −2.2 | Generic enzyme | X | |
| Pre-mRNA-processing factor 19 | Q9UMS4 | 27339 | NMP200 | 1.24 | 0.00673 | −2.2 | Generic binding protein | X | X |
| La-related protein 4 | Q71RC2 | 113251 | LARP4 | 2.21 | 0.00918 | −2.2 | Generic binding protein | X | |
| Lanosterol 14-α demethylase | Q16850 | 1595 | CYP51A1 | 0.79 | 0.05002 | −2.1 | Generic enzyme | X | |
| RNA-binding protein FUS | P35637 | 2521 | FUS | 0.91 | 0.04299 | −2.1 | Generic binding protein | X | |
| 10 kDa heat shock protein, mitochondrial | P61604 | 3336 | HSP10 (mitochondrial) | 1.27 | 0.00704 | −2.0 | Generic binding protein | X | |
| UDP-glucose:glycoprotein glucosyltransferase 1 | Q9NYU2 | 56886 | UGCGL1 | 1.89 | 0.00092 | −2.0 | Generic enzyme | ||
| Hypoxia upregulated protein 1 | Q9Y4L1 | 10525 | HYOU1 | 0.91 | 0.02828 | −2.0 | Generic binding protein | X | |
| Staphylococcal nuclease domain-containing protein 1 | Q7KZF4 | 27044 | SND1 | 1.80 | 0.01223 | −2.0 | Generic binding protein | X | |
| ELAV-like protein 1 | Q15717 | 1994 | ELAVL1 (HuR) | 0.93 | 0.02877 | −2.0 | Generic binding protein | X | |
| B-cell receptor-associated protein 31 | P51572 | 10134 | BCAP31 | 1.02 | 0.02750 | −1.9 | Generic binding protein | ||
| 26S proteasome non-ATPase regulatory subunit 7 | P51665 | 5713 | PSMD7 | 0.79 | 0.04622 | −1.9 | Generic binding protein | X | |
| Elongation factor Tu, mitochondrial | P49411 | 7284 | TUFM | 0.85 | 0.02811 | −1.9 | Generic binding protein | ||
| Prolyl 4-hydroxylase subunit α-2 | O15460 | 8974 | P4HA | 0.82 | 0.03704 | −1.9 | Generic enzyme | X | |
| P37 AUF1 | Q12771 | 0.71 | 0.04582 | −1.8 | |||||
| Ornithine aminotransferase, mitochondrial | P04181 | 4942 | OAT | 0.81 | 0.05087 | −1.8 | Generic enzyme | ||
| Actin-related protein 2/3 complex subunit 1B | O15143 | 10095 | ARPC1 | 0.93 | 0.01943 | −1.7 | Generic binding protein | X | |
| Utrophin | P46939 | 7402 | Utrophin | 1.48 | 0.00458 | −1.7 | Generic binding protein | X | X |
| Vesicle-associated membrane protein-associated protein A | Q9P0L0 | 9218 | VAPA | 1.11 | 0.01762 | −1.7 | Generic binding protein | X | |
| Ras-related protein Rab-1A | P62820 | 5861 | Rab-1A | 1.08 | 0.01950 | −1.7 | RAS - superfamily | ||
| Calnexin | P27824 | 821 | Calnexin | 0.79 | 0.04528 | −1.7 | Generic binding protein | X | |
| α-Aminoadipic semialdehyde dehydrogenase | P49419 | 501 | AL7A1 | 1.82 | 0.03742 | −1.7 | Generic enzyme | X | |
| Ras-related protein Rab-1B | Q9H0U4 | 81876 | Rab-1B | 0.99 | 0.01658 | −1.7 | RAS - superfamily | ||
| Calreticulin | P27797 | 811 | Calreticulin | 1.55 | 0.00609 | −1.7 | Generic binding protein | X | |
| Polymerase I and transcript release factor | Q6NZI2 | 284119 | PTRF | 1.73 | 0.01208 | −1.7 | Generic binding protein | X | X |
| Neutral α-glucosidase AB | Q14697 | 23193 | GANAB | 1.30 | 0.00599 | −1.6 | Generic enzyme | ||
| Pyruvate dehydrogenase E1 component subunit α | P08559 | 5160 | PDH | 0.88 | 0.07592 | −1.6 | Generic enzyme | ||
| Coatomer subunit α | P53621 | 1314 | COPA | 1.06 | 0.01301 | −1.6 | Generic binding protein | X | X |
| Heterogeneous nuclear ribonucleoprotein F | P52597 | 3185 | hnRNP F | 0.75 | 0.04082 | −1.6 | Generic binding protein | ||
| Serpin H1 | P50454 | 871 | HSP47 | 1.25 | 0.02301 | −1.6 | Generic binding protein | X | |
| Nischarin | Q9Y2I1 | 11188 | IRAS | 1.03 | 0.02231 | −1.6 | Generic binding protein | ||
| Neuroblast differentiation-associated protein AHNAK | Q09666 | 79026 | AHNAK | 1.38 | 0.00585 | −1.6 | Generic binding protein | X | |
| Endoplasmin | P14625 | 7184 | Endoplasmin | 1.21 | 0.02263 | −1.5 | Generic binding protein | X | |
| 60 kDa heat shock protein, mitochondrial | P10809 | 3329 | HSP60 | 1.05 | 0.03181 | −1.5 | Generic binding protein | ||
| Malate dehydrogenase | Q6FHZ0 | 4191 | MDH2 | 1.15 | 0.01381 | −1.5 | Generic enzyme | X | |
X denotes whether a protein was included in the indicated analysis and whether its decrease by S1 was prevented by pretreatment of L2 cells with HMW-HA. HA, hyaluronan (hyaluronic acid); HMW, high molecular weight.