Table 3.
Enrichment by process networks (S1 treated vs. vehicle)
| # | Network | Total | P Value | FDR | In Data | Network Objects from Active Data |
|---|---|---|---|---|---|---|
| 1 | Protein folding_Response to unfolded proteins | 71 | 1.1E-11 | 8.8E-10 | 12 | HSP90, HSP27, HSP47, Endoplasmin, HSP70, HSP60, Calreticulin, HYOU1, HSP105, HSP10 (mitochondrial), HSPA4, Calnexin |
| 2 | Protein folding_Folding in normal condition | 119 | 5.5E-09 | 2.1E-07 | 12 | HSP90, HSP27, HSP47, α crystallin B, Endoplasmin, HSP70, HSP60, HYOU1, HSP105, HSP10 (mitochondrial), HSPA4, PPID |
| 3 | Protein folding_ER and cytoplasm | 44 | 4.4E-07 | 1.1E-05 | 7 | HSP90, HSP47, HSP70, Calreticulin, UGCGL1, HYOU1, Calnexin |
| 4 | Immune response_Phagosome in antigen presentation | 241 | 6.3E-05 | 1.2E-03 | 11 | HSP90, PSMA4, CRK, Endoplasmin, PSMD7, HSP70, Calreticulin, Vinculin, PSMB5, Calnexin, PSMD12 |
| 5 | Cytoskeleton_Regulation of cytoskeleton rearrangement (RhoA) | 183 | 1.8E-04 | 2.8E-03 | 9 | ARPC1B, CRK, ARPC1, Vinculin, ARPC4, Plectin 1, Tubulin β, DIA1, Tubulin β 2 |
| 6 | Cytoskeleton_Intermediate filaments (RhoA) | 81 | 2.6E-04 | 2.9E-03 | 6 | KIF5B, Kinesin heavy chain, Plectin 1, Tubulin β, Tubulin β 2, Desmoplakin |
| 7 | Immune response_Antigen presentation | 193 | 2.6E-04 | 2.9E-03 | 9 | HSP90, PSMA4, Endoplasmin, PSMD7, HSP70, Calreticulin, PSMB5, Calnexin, PSMD12 |
| 8 | Cytoskeleton_Actin filaments (RhoA) | 176 | 7.0E-04 | 6.8E-03 | 8 | Utrophin, ARPC1B, CRK, ARPC1, Vinculin, ARPC4, Plectin 1, DIA1 |
| 9 | Proteolysis_Ubiquitin-proteasomal proteolysis | 166 | 2.3E-03 | 2.0E-02 | 7 | HSP90, PSMA4, PSMD7, HSP70, PSMB5, PSMD12, Elongin B |
| 10 | Protein folding_Protein folding nucleus | 58 | 3.8E-03 | 3.0E-02 | 4 | HSP90, HSP70, HYOU1, HSPA4 |
| 11 | Transcription_mRNA processing | 160 | 8.5E-03 | 6.0E-02 | 6 | PCBP-1, SF3A1, hnRNP M, CPSF5, NMP200, hnRNP F |
| 12 | Cell adhesion_Integrin-mediated cell-matrix adhesion (RhoA) | 214 | 9.4E-03 | 6.1E-02 | 7 | Galectin-1, CRK, Vinculin, Tubulin β, DIA1, Tubulin β 2, IRAS |
| 13 | Signal transduction_Insulin signaling | 171 | 4.1E-02 | 2.4E-01 | 5 | PDH, PDH β, ACLY, PDH α, PDHA (somatic) |
| 14 | Translation_Elongation-Termination | 232 | 4.3E-02 | 2.4E-01 | 6 | eEF1A, RPS26, eEF1A1, SRP54, RPL6, RPL5 |
| 15 | Cell cycle_Mitosis | 179 | 4.8E-02 | 2.5E-01 | 5 | NUMA1, CRK, Tubulin β, SMC3, CSE1L |
| 16 | Cell cycle_Meiosis | 106 | 1.1E-01 | 5.3E-01 | 3 | HSP70, Tubulin β, SMC3 |
| 17 | Cytoskeleton_Spindle microtubules (RhoA) | 109 | 1.2E-01 | 5.3E-01 | 3 | NUMA1, Tubulin β, SMC3 |
| 18 | Translation_Translation initiation | 171 | 1.2E-01 | 5.3E-01 | 4 | RPS26, RPL6, RENT1, RPL5 |
| 19 | Cytoskeleton_Cytoplasmic microtubules (RhoA) | 115 | 1.4E-01 | 5.6E-01 | 3 | KIF5B, Kinesin heavy chain, Tubulin β |
| 20 | Signal transduction_Androgen receptor nuclear signaling | 126 | 1.6E-01 | 6.4E-01 | 3 | HSP90, Calreticulin, ELAVL1 (HuR) |
| 21 | Apoptosis_Endoplasmic reticulum stress pathway | 89 | 2.6E-01 | 9.3E-01 | 2 | Endoplasmin, BCAP31 |