Table 5.
Top network list (HMW-HA vs. vehicle)
| # | Network | GO Processes | Total Nodes | Seed Nodes | P Value | z Score | G Score |
|---|---|---|---|---|---|---|---|
| 1 | E2F5, Histone H1, G0/G1switch 2, CDK3, Ebp1 | Cellular response to stress (38.4%; 1.909e-13), nucleic acid metabolic process (41.4%; 3.344e-13), establishment of localization (58.6%; 1.255e-12), cellular macromolecule catabolic process (25.3%; 4.243e-12), cellular localization (45.5%; 9.177e-12) | 100 | 81 | 6.1E-284 | 440.04 | 440.04 |
| 2 | MCM4, MCM2, E2F1, MCM10, Geminin | G1/S transition of mitotic cell cycle (20.2%; 2.689e-20), cell cycle G1/S phase transition (20.2%; 3.197e-20), DNA replication initiation (11.7%; 6.811e-18), DNA replication (19.1%; 1.542e-17), nucleic acid metabolic process (45.7%; 1.169e-15) | 95 | 77 | 2.9E-268 | 429.18 | 429.18 |
| 3 | Histone H2B, RBP-J kappa (CBF1), c-Jun, NF-κB, REV-ERBα | Negative regulation of gene expression (37.6%; 5.810e-10), cellular macromolecule catabolic process (23.5%; 2.256e-09), macromolecule catabolic process (23.5%; 4.291e-08), positive regulation of cellular process (61.2%; 4.466e-08), viral process (21.2%; 7.526e-08) | 85 | 65 | 1.0E-219 | 382.99 | 382.99 |
| 4 | HIP1, VAMP2, Synaptotagmin I, Caspase-3, Clathrin | Response to abiotic stimulus (45.0%; 3.968e-30), regulation of transport (50.7%; 9.340e-29), response to organonitrogen compound (42.9%; 2.997e-28), response to nitrogen compound (43.6%; 1.069e-27), positive regulation of transport (39.3%; 2.645e-27) | 154 | 63 | 4.3E-188 | 280.3 | 280.3 |
| 5 | MAP-1B, ERK1/2, WNT, L-Glutamic acid extracellular region, BDNF | Establishment of localization in cell (51.8%; 2.860e-17), establishment of localization (68.7%; 6.767e-17), transport (66.3%; 7.749e-16), localization (73.5%; 2.307e-15), cellular localization (54.2%; 2.654e-15) | 93 | 56 | 1.4E-178 | 318.87 | 318.87 |
| 6 | NF-κB1 (p50), DLC1 (Dynein LC8a), MTA1, ESR1 (nuclear), PR (nuclear) | Nucleic acid metabolic process (48.1%; 2.864e-10), cellular nitrogen compound metabolic process (57.7%; 5.046e-10), nucleobase-containing compound metabolic process (50.0%; 4.050e-09), organic cyclic compound metabolic process (53.8%; 4.856e-09), metabolic process (84.6%; 4.918e-09) | 53 | 44 | 7.9E-149 | 328.32 | 328.32 |
| 7 | NF-κB1 (p50), DLC1 (Dynein LC8a), REA, ESR1 (nuclear), PR (nuclear) | Nucleic acid metabolic process (48.1%; 2.864e-10), cellular nitrogen compound metabolic process (57.7%; 5.046e-10), nucleobase-containing compound metabolic process (50.0%; 4.050e-09), organic cyclic compound metabolic process (53.8%; 4.856e-09), metabolic process (84.6%; 4.918e-09) | 53 | 44 | 7.9E-149 | 328.32 | 328.32 |
| 8 | Histone H2, Testosterone intracellular, Activin A, Inhibin, NCOA4 (ARA70) | Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (21.2%; 1.831e-14), activin receptor signaling pathway (13.5%; 1.389e-12), response to organic substance (65.4%; 3.507e-12), regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (23.1%; 7.720e-12), positive regulation of follicle-stimulating hormone secretion (9.6%; 3.467e-11) | 56 | 36 | 6.6E-115 | 266.1 | 266.1 |
| 9 | p53, NF-κB, MDM2, BRIP1, RAD54B | Protein sumoylation (17.2%; 2.807e-15), double-strand break repair (22.4%; 1.676e-14), cellular response to stress (48.3%; 3.211e-13), positive regulation of protein metabolic process (46.6%; 2.677e-12), positive regulation of cellular protein metabolic process (44.8%; 4.875e-12) | 58 | 34 | 1.8E-105 | 242.48 | 242.48 |
| 10 | MAT2A, Bcl-XS, IGF-2, Ethanol intracellular, IGF-1 | Phosphatidylinositol 3-kinase signaling (23.5%; 2.938e-15), phosphatidylinositol-mediated signaling (26.5%; 5.712e-14), response to peptide (47.1%; 6.707e-14), inositol lipid-mediated signaling (26.5%; 8.453e-14), response to peptide hormone (44.1%; 1.502e-13) | 50 | 19 | 1.4E-55 | 157.34 | 157.34 |
| 11 | ERP5, ATF-4, GRP78, 19S regulator, JIK | Response to endoplasmic reticulum stress (45.7%; 9.974e-21), cellular response to stress (74.3%; 6.606e-19), intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (25.7%; 7.354e-17), response to stress (88.6%; 7.790e-17), regulation of endoplasmic reticulum unfolded protein response (22.9%; 1.856e-16) | 39 | 13 | 2.7E-36 | 113.01 | 113.01 |
GO, Gene Ontology; HA, hyaluronan (hyaluronic acid); HMW, high molecular weight.