Table 6.
Rat L2 proteomic S1-Tx cross correlated with pathway associations using transcriptomic data from five human cell lines exposed to SARS-CoV-2 virus
| Geneset | Pathway | #Targets | NES | P Value | q Value |
|---|---|---|---|---|---|
| 1. NHBE (Normal Human Bronchial Epithelial) | |||||
| HALLMARK | E2F | 195 | −1.4 | 0.0091 | 0.2044 |
| 2. A549 (adenocarcinoma human alveolar basal epithelial cells) | |||||
| HALLMARK | E2F | 197 | −3.1 | 0.0000 | 0.0000 |
| HALLMARK | G2M checkpoint | 194 | −2.7 | 0.0000 | 0.0000 |
| HALLMARK | Fatty acid metabolism | 150 | −1.5 | 0.0105 | 0.0320 |
| 3. A549-ACE2 | |||||
| HALLMARK | Fatty acid metabolism | 150 | −2.3 | 0.0000 | 0.0000 |
| HALLMARK | E2F | 196 | −1.8 | 0.0000 | 0.0002 |
| REACTOME | E2F-mediated DNA replication | 22 | −1.9 | 0.0056 | 0.0051 |
| BIOCARTA | CREB | 22 | −1.6 | 0.0295 | 0/0661 |
| 4. HAE (Human Airway Epithelial) | |||||
| HALLMARK | Fatty acid metabolism | 151 | −1.6 | 0.0000 | 0.0177 |
| BIOCARTA | CREB | 21 | −1.7 | 0.0037 | 0.1270 |
| 5. Calu (nonsmall-cell lung cancer) | |||||
| HALLMARK | E2F | 197 | −3 | 0.0000 | 0.0000 |
| HALLMARK | G2M checkpoint | 194 | −2.3 | 0.0000 | 0.0000 |
| HALLMARK | Fatty acid metabolism | 147 | −2.0 | 0.0000 | 0.0000 |
| REACTOME | E2F-mediated DNA replication | 22 | −1.9 | 0.0030 | 0.0119 |
| KEGG | Cell cycle | 124 | −1.6 | 0.0081 | 0.0510 |