Figure 6.

Impact of lentiviral INPP4B upregulation in etoposide resistant RB (etop) cells on tumor formation in CAM assays. (a) The left photo panel depicts CAM tumors in ovo, and the right panel measuring (in cm) of excised tumors. In vivo CAM assays revealed that tumors forming from INPP4B overexpressing (OE), etoposide resistant (Etop) Y79, and RB355 cells were smaller than those developing from control cells (ctr). (b–d) Graphical evaluation of CAM tumor weight (b), size (c), and tumor formation capacity (d). A student's t-test was used to calculate statistical differences (ns p > 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001) between control and experimental groups.