Table 2.
Responsive gene selection (RGS) after INPP4B overexpression in etoposide-resistant Y79 cells. Genes with positive fold change (FC) values represent upregulated genes after INPP4B overexpression, while negative FC values indicate downregulated genes.
| Gene symbols | Description of upregulated DEGs | FC | P-value |
| INPP4B | Tumor suppressor; involved in phosphatidylinositol signaling | 6.41 | 0.000 |
| IER3 | Protects cells from fas or tumor necrosis factor type alpha induced apoptosis | 4.30 | 0.021 |
| WNT11 | Implicated in oncogenesis and several developmental processes; member of the WNT gene family | 4.20 | 0.025 |
| CAPG | Reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner | 4.00 | 0.021 |
| RF00424 | Small cajal body-specific RNA 16 | 3.97 | 0.047 |
| IL32 | Encodes a member of the cytokine family | 3.87 | 0.026 |
| HSD17B2 | Enables estradiol 17-beta-dehydrogenase and testosterone dehydrogenase (NAD+) activity; involved in response to retinoic acid | 3.69 | 0.006 |
| HCST | Activates phosphatidylinositol 3-kinase dependent signaling pathways; receptor complex may have a role in cell survival and proliferation | 3.52 | 0.037 |
| MIR4521 | Reduces proliferation and invasion of medulloblastoma cells; induces programmed cell death via activation of caspase 3/7 | 3.51 | 0.044 |
| SLC6A4 | Encodes an integral membrane protein that transports serotonin from synaptic spaces into presynaptic neurons | 3.09 | 0.034 |
| LRTM2 | Predicted to be involved in axon guidance and negative chemotaxis | 2.71 | 0.035 |
| TMBIM1 | Negative regulator of extrinsic apoptotic signaling pathway via death domain receptors | 2.40 | 0.003 |
| CCDC153 | Protein coding; enables identical protein binding activity | 2.22 | 0.036 |
| MYCL | Predicted to enable DNA-binding transcription factor activity | 2.12 | 0.035 |
| FBXO32 | Encodes a member of the F-box protein family | 1.89 | 0.030 |
| IGSF5 | Predicted to enable PDZ domain binding activity and cell-cell adhesion | 1.71 | 0.047 |
|
| |||
| Gene symbols | Description of downregulated DEGs | FC | P-value |
| HYAL3 | Regulates turnover of hyaluronan, which plays a critical role in biological like cell proliferation, migration and differentiation | −4.82 | 0.004 |
| ZFR2 | Predicted to enable single- and double-stranded RNA binding activity | −4.09 | 0.031 |
| GALP | Encodes a member of the galanin family of neuro-peptides; may serve as a marker for neuroblastic tumors | −3.96 | 0.014 |
| IL34 | Cytokine that promotes the differentiation and viability of monocytes and macrophages through colony-stimulating factor-1 receptor | −3.49 | 0.040 |
| EMP1 | Potential biomarker for tumor diagnosis and prognosis of several cancers | −3.45 | 0.045 |
| FDCSP | Potential contribution to tumor metastases by promoting cancer cell migration and invasion | −2.92 | 0.048 |
| NR4A2 | Encoded protein may act as a transcription factor | −2.67 | 0.032 |
| ZNF761 | Predicted to enable DNA-binding transcription factor activity | −1.46 | 0.046 |