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. 2022 Nov 29;396(4):669–682. doi: 10.1007/s00210-022-02348-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Positive chronotropic effect of levosimendan in the mouse atrium in the presence of rolipram. Original recording and summarized data. Levosimendan has a positive chronotropic effect in the mouse heart that is potentiated by the phosphodiesterase IV inhibitor rolipram. Ordinates in (A) indicate the effect of levosimendan on force of contraction or in beats per minute (B: bpm) in isolated spontaneously beating right atrial preparations from mouse hearts. Horizontal bars in (A) indicate time in minutes (min). Vertical bars in (A) indicate force of contraction in millinewton (mN). *p < 0.05 versus Ctr (t-test). Numbers in brackets indicate the number of experiments