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. 2022 Oct 10;44(4):801–810. doi: 10.1038/s41401-022-00993-5

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 6 — a C57BL/6 J mice were pretreated with or without AZD4547 (5 or 10 mg/kg) and then induced SIRS with TNFα and z‐VAD‐FMK. The body temperature (left panel) and reduction in body temperature over time (right panel) were measured at indicated time. b Survival curve of the vehicle control and AZD4547 treated mice after TNFα treatment are shown (n = 5). c After SIRS induction for 2 or 6 h, serum levels of IL‐6 and IL-1α were determined by ELISA. d Representative section of H&E and TUNEL staining of the ileum and liver with or without AZD4547 treatment after TNF-α injection 4 h later. *P < 0.05, ***P < 0.001. TUNEL assay was not performed for WT group.