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. 2022 Oct 13;44(4):766–779. doi: 10.1038/s41401-022-01000-7

Fig. 5. TRPV1 function determines the clearance of myelin debris following demyelination.

Fig. 5

a Representative images for compact myelin by FluoroMyelin staining, scale bar = 100 μm. b Quantification of FluoroMyelin staining in the corpus callosum (mean ± SEM; n = 4 mice for each group; WT CPZ + CAP vs. WT CPZ, Trpv1−/− CPZ vs. WT CPZ, *P < 0.05, **P < 0.01 by unpaired two-tailed t-test). c Myelin debris in the corpus callosum was assessed by immunostaining using a specific antibody to label degraded myelin basic protein (dMBP); scale bar = 20 μm. d Quantification of dMBP positive staining in the corpus callosum (mean ± SEM; n = 3 mice for each group; WT CPZ + CAP vs. WT CPZ, Trpv1−/− CPZ vs. WT CPZ, *P < 0.05, ***P < 0.001 by unpaired two-tailed t-test). e Myelin debris was detected using Oil Red O staining and presented as red lipid droplet; scale bar = 50 μm.