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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1990 Dec;49(12):1017–1020. doi: 10.1136/ard.49.12.1017

Nodal generalised osteoarthritis is an autoimmune disease.

M Doherty 1, M Pattrick 1, R Powell 1
PMCID: PMC1004302  PMID: 2270962

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acheson R. M., Collart A. B. New Haven survey of joint diseases. XVII. Relationship between some systemic characteristics and osteoarthrosis in a general population. Ann Rheum Dis. 1975 Oct;34(5):379–387. doi: 10.1136/ard.34.5.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alexander G. M., Dieppe P. A., Doherty M., Scott D. G. Pyrophosphate arthropathy: a study of metabolic associations and laboratory data. Ann Rheum Dis. 1982 Aug;41(4):377–381. doi: 10.1136/ard.41.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Altman R. D., Gray R. Inflammation in osteoarthritis. Clin Rheum Dis. 1985 Aug;11(2):353–365. [PubMed] [Google Scholar]
  4. Ansar Ahmed S., Talal N. Sex hormones and autoimmune rheumatic disorders. Scand J Rheumatol. 1989;18(2):69–76. doi: 10.3109/03009748909099921. [DOI] [PubMed] [Google Scholar]
  5. Baldwin R. N., Mijovic C., Fletcher J., Bradwell A. R., Barnett A. H., Hockaday T. D. Immunoglobulin heavy chain phenotypes and background retinopathy in non-insulin dependent diabetics. BMJ. 1988 Oct 29;297(6656):1104–1105. doi: 10.1136/bmj.297.6656.1104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Benavides G., Cervantes A., Silva B., Katona G., Lardizabal J. HLA and Heberden's nodes in Mexican Mestizos. Clin Rheumatol. 1985 Mar;4(1):97–98. doi: 10.1007/BF02032327. [DOI] [PubMed] [Google Scholar]
  7. Brodsky A., Appelboom T., Govaerts A., Famaey J. P. Antigènes HLA et nodosités d'Heberden. Acta Rhumatol Belg. 1979 Apr-Jun;3(2):95–103. [PubMed] [Google Scholar]
  8. COBB S., MERCHANT W. R., RUBIN T. The relation of symptoms to osteoarthritis. J Chronic Dis. 1957 Feb;5(2):197–204. doi: 10.1016/0021-9681(57)90135-2. [DOI] [PubMed] [Google Scholar]
  9. CRAIN D. C. Interphalangeal osteoarthritis. JAMA. 1961 Mar 25;175:1049–1053. doi: 10.1001/jama.1961.03040120011003. [DOI] [PubMed] [Google Scholar]
  10. Cooke T. D. Immune pathology in polyarticular osteoarthritis. Clin Orthop Relat Res. 1986 Dec;(213):41–49. [PubMed] [Google Scholar]
  11. Cooke T. D. Pathogenetic mechanisms in polyarticular osteoarthritis. Clin Rheum Dis. 1985 Aug;11(2):203–238. [PubMed] [Google Scholar]
  12. Cox D. W., Markovic V. D., Teshima I. E. Genes for immunoglobulin heavy chains and for alpha 1-antitrypsin are localized to specific regions of chromosome 14q. Nature. 1982 Jun 3;297(5865):428–430. doi: 10.1038/297428a0. [DOI] [PubMed] [Google Scholar]
  13. Dahlberg P. A., Holmlund G., Karlsson F. A., Säfwenberg J. HLA-A, -B, -C and -DR antigens in patients with Graves' disease and their correlation with signs and clinical course. Acta Endocrinol (Copenh) 1981 May;97(1):42–47. doi: 10.1530/acta.0.0970042. [DOI] [PubMed] [Google Scholar]
  14. Dieppe P. A., Doherty M., Macfarlane D. G., Hutton C. W., Bradfield J. W., Watt I. Apatite associated destructive arthritis. Br J Rheumatol. 1984 May;23(2):84–91. doi: 10.1093/rheumatology/23.2.84. [DOI] [PubMed] [Google Scholar]
  15. Dieppe P., Watt I. Crystal deposition in osteoarthritis: an opportunistic event? Clin Rheum Dis. 1985 Aug;11(2):367–392. [PubMed] [Google Scholar]
  16. Doherty M. 'Chondroprotection' by non-steroidal anti-inflammatory drugs. Ann Rheum Dis. 1989 Aug;48(8):619–621. doi: 10.1136/ard.48.8.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Doherty M., Dieppe P. Clinical aspects of calcium pyrophosphate dihydrate crystal deposition. Rheum Dis Clin North Am. 1988 Aug;14(2):395–414. [PubMed] [Google Scholar]
  18. Doherty M., Watt I., Dieppe P. Influence of primary generalised osteoarthritis on development of secondary osteoarthritis. Lancet. 1983 Jul 2;2(8340):8–11. doi: 10.1016/s0140-6736(83)90003-x. [DOI] [PubMed] [Google Scholar]
  19. Ercilla M. G., Brancos M. A., Breysse Y., Alonso G., Vives J., Castillo R., Querol J. R. HLA antigens in Forestier's disease, ankylosing spondylitis, and polyarthrosis of the hands. J Rheumatol Suppl. 1977;3:89–93. [PubMed] [Google Scholar]
  20. Goldberg V. M., Kresina T. F. Immunology of articular cartilage. J Rheumatol. 1987 May;14(Spec No):73–76. [PubMed] [Google Scholar]
  21. Goldstein R., Arnett F. C. The genetics of rheumatic disease in man. Rheum Dis Clin North Am. 1987 Dec;13(3):487–510. [PubMed] [Google Scholar]
  22. Hadler N. M. Industrial rheumatology. Clinical investigations into the influence of the pattern of usage of the pattern of regional musculoskeletal disease. Arthritis Rheum. 1977 May;20(4):1019–1025. doi: 10.1002/art.1780200417. [DOI] [PubMed] [Google Scholar]
  23. Hull R., Pope F. M. Osteoarthritis and cartilage collagen genes. Lancet. 1989 Jun 10;1(8650):1337–1338. doi: 10.1016/s0140-6736(89)92741-4. [DOI] [PubMed] [Google Scholar]
  24. Hutton C. W. Generalised osteoarthritis: an evolutionary problem? Lancet. 1987 Jun 27;1(8548):1463–1465. doi: 10.1016/s0140-6736(87)92209-4. [DOI] [PubMed] [Google Scholar]
  25. Jasin H. E. Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 1985 Mar;28(3):241–248. doi: 10.1002/art.1780280302. [DOI] [PubMed] [Google Scholar]
  26. Johnell O., Hulth A., Henricson A. T-lymphocyte subsets and HLA-DR-expressing cells in the osteoarthritic synovialis. Scand J Rheumatol. 1985;14(3):259–264. doi: 10.3109/03009748509100403. [DOI] [PubMed] [Google Scholar]
  27. KELLGREN J. H., MOORE R. Generalized osteoarthritis and Heberden's nodes. Br Med J. 1952 Jan 26;1(4751):181–187. doi: 10.1136/bmj.1.4751.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Komatireddy G. R., Ellman M. H., Brown N. L. Lack of association between hypothyroidism and chondrocalcinosis. J Rheumatol. 1989 Jun;16(6):807–808. [PubMed] [Google Scholar]
  29. Lindblad S., Hedfors E. Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis. Arthritis Rheum. 1987 Oct;30(10):1081–1088. doi: 10.1002/art.1780301001. [DOI] [PubMed] [Google Scholar]
  30. Marks J. S., Stewart I. M., Hardinge K. Primary osteoathrosis of the hip and Heberden's nodes. Ann Rheum Dis. 1979 Apr;38(2):107–111. doi: 10.1136/ard.38.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. McGoldrick F., O'Brien T. M. Osteoarthritis of the hip and Heberden's nodes. Ann Rheum Dis. 1989 Jan;48(1):53–55. doi: 10.1136/ard.48.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Morgan K. What do anti-collagen antibodies mean? Ann Rheum Dis. 1990 Jan;49(1):62–65. doi: 10.1136/ard.49.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Nakao Y., Matsumoto H., Miyazaki T., Nishitani H., Takatsuki K., Kasukawa R., Nakayama S., Izumi S., Fujita T., Tsuji K. IgG heavy chain allotypes (Gm) in autoimmune diseases. Clin Exp Immunol. 1980 Oct;42(1):20–26. [PMC free article] [PubMed] [Google Scholar]
  34. Oldstone M. B. Molecular mimicry and autoimmune disease. Cell. 1987 Sep 11;50(6):819–820. doi: 10.1016/0092-8674(87)90507-1. [DOI] [PubMed] [Google Scholar]
  35. Palotie A., Väisänen P., Ott J., Ryhänen L., Elima K., Vikkula M., Cheah K., Vuorio E., Peltonen L. Predisposition to familial osteoarthrosis linked to type II collagen gene. Lancet. 1989 Apr 29;1(8644):924–927. doi: 10.1016/s0140-6736(89)92507-5. [DOI] [PubMed] [Google Scholar]
  36. Pattrick M., Aldridge S., Hamilton E., Manhire A., Doherty M. A controlled study of hand function in nodal and erosive osteoarthritis. Ann Rheum Dis. 1989 Dec;48(12):978–982. doi: 10.1136/ard.48.12.978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Pattrick M., Manhire A., Ward A. M., Doherty M. HLA-A, B antigens and alpha 1-antitrypsin phenotypes in nodal generalised osteoarthritis and erosive osteoarthritis. Ann Rheum Dis. 1989 Jun;48(6):470–475. doi: 10.1136/ard.48.6.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Peyron J. G. Epidemiologic and etiologic approach of osteoarthritis. Semin Arthritis Rheum. 1979 May;8(4):288–306. doi: 10.1016/0049-0172(79)90006-4. [DOI] [PubMed] [Google Scholar]
  39. Radin E. L., Burr D. B. Hypothesis: joints can heal. Semin Arthritis Rheum. 1984 Feb;13(3):293–302. doi: 10.1016/0049-0172(84)90031-3. [DOI] [PubMed] [Google Scholar]
  40. Radin E. L., Parker H. G., Paul I. L. Pattern of degenerative arthritis. Preferential involvement of distal finger-joints. Lancet. 1971 Feb 20;1(7695):377–379. doi: 10.1016/s0140-6736(71)92213-6. [DOI] [PubMed] [Google Scholar]
  41. Rosner I. A., Goldberg V. M., Moskowitz R. W. Estrogens and osteoarthritis. Clin Orthop Relat Res. 1986 Dec;(213):77–83. [PubMed] [Google Scholar]
  42. Rothwell A. G., Bentley G. Chondrocyte multiplication in osteoarthritic articular cartilage. J Bone Joint Surg Br. 1973 Aug;55(3):588–594. [PubMed] [Google Scholar]
  43. SOKOLOFF L. Natural history of degenerative joint disease in small laboratory animals. I. Pathological anatomy of degenerative joint disease in mice. AMA Arch Pathol. 1956 Aug;62(2):118–128. [PubMed] [Google Scholar]
  44. Sokoloff L. Osteoarthritis as a remodeling process. J Rheumatol. 1987 May;14(Spec No):7–10. [PubMed] [Google Scholar]
  45. Solomon L. Patterns of osteoarthritis of the hip. J Bone Joint Surg Br. 1976 May;58(2):176–183. doi: 10.1302/0301-620X.58B2.932079. [DOI] [PubMed] [Google Scholar]
  46. Spector T. D., Brown G. C., Silman A. J. Increased rates of previous hysterectomy and gynaecological operations in women with osteoarthritis. BMJ. 1988 Oct 8;297(6653):899–900. doi: 10.1136/bmj.297.6653.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Spector T. D., Campion G. D. Generalised osteoarthritis: a hormonally mediated disease. Ann Rheum Dis. 1989 Jun;48(6):523–527. doi: 10.1136/ard.48.6.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Whittingham S., Mathews J. D., Schanfield M. S., Matthews J. V., Tait B. D., Morris P. J., Mackay I. R. Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen. Clin Exp Immunol. 1980 Apr;40(1):8–15. [PMC free article] [PubMed] [Google Scholar]

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