Table 2.

Comparison of viral infection parameters and biomarker levels between younger (≤60 years old) and elderly (>65 years old) donors.

	≤60 years old donors	>65 years old donors	Statistical analysis
n	4	4
Viral peak (day)	3.75 ± 0.500	3.50 ± 0.577	NS
Viral peak (Log, PFU/mL)	5.63 ± 1.08	6.50 ± 0.197	NS
Viral load (slope Day 3–6)	0.251 ± 0.116	0.005 ± 0.061	p < 0.05
Viral load (slope Day 3–10)	0.169 ± 0.107	0.0446 ± 0.0450	NS
Viral load (AUC [log, PFU/mL] Day 3–10)	25.6 ± 6.38	36.5 ± 1.09	p < 0.05
PCR Viral load (AUC [log, copy/mL] Day 3–10)	27.3 ± 4.70	35.1 ± 1.23	p < 0.05
AUC CXCL8 (pg/mL) Day 3–10	7,590 ± 3,440	13,000 ± 6,350	NS
AUC IL-6 (pg/mL) Day 3–10	246 ± 266	137 ± 160	NS
AUC RANTES (pg/mL) Day 3–10	87.2 ± 41.0	622 ± 416	p < 0.05
AUC CXCL10 (pg/mL) Day 3–10*	6,020 ± 2,670	133,000 ± 191,000	NS
AUC mucin (AU) Day 3–10	8,660 ± 6,580	156,000 ± 201,000	NS
AUC dsDNA (ng/mL) Day 3–10	1,920 ± 1,610	5,650 ± 1,280	p < 0.05
AUC LDH (OD) Day 3–10*	4.54 ± 0.540	5.61 ± 0.408	p < 0.05

Mean ± SD is shown. PFU, plaque forming unit, *n = 3 of ≤ 60 years old donors. AU: absorbance units, OD: optical density, NS: not significant.