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. 2022 Oct 7;44(4):877–887. doi: 10.1038/s41401-022-00999-z

Fig. 4. X-ray crystal structure of WDR5 in complexed with compound 19.

Fig. 4

a A surface representation of compound 19 and MYC-MbIIIb, KANSL2, RbBP5 peptides interactions with WDR5 at WBM site. b Detailed interactions of compound 19 with pivotal residues of WDR5 is shown as sticks and hydrogen bonds are shown as black dash lines. c Superimposition of the conserved MbIIIb, KANSL2 and RbBP5 in complex with WDR5, and the sequence alignment of the peptides. d Superimposed binding modes of compound 19 and MYC-MbIIIb with WDR5 at WBM site.